Abstract:Objective To explore the significance of ABO blood group in the incidence, development and prognosis of nasopharyngeal carcinoma (NPC). Methods One hundred and eighty-eight patients who were newly diagnosed as NPC in Hunan Cancer Hospital from June to December 2013 were enrolled in this study. Blood samples of the patients before treatment were collected for ABO blood group and EBV-DNA testing. All the patients were followed up for more than five years. Kaplan-Meier method was used to draw the survival curve, and Log-rank test was employed to compare the differences in the overall survival (OS) rates. Results There were no statistically significant differences in gender, age, smoking history, drinking history, TNM stage, T stage, N stage, M stage, EBV-DNA level and chemoradiotherapy status of patients with different blood groups (all P>0.05). No statistically significant difference was found in the distribution of ABO blood type between NPC group and the control group (P=0.352). ABO blood group was not correlated with TNM stage, distant metastasis and EBV-DNA level (P>0.05). No statistically significant difference was observed in the OS rates among patients with different blood groups (P=0.215). In addition, there was no statistically significant difference in the OS rates between type A and non-type A groups, between type B and non-type B groups as well as between type O and non-type O groups (all P>0.05). The OS rate was significantly higher in non-AB group than in AB group (P=0.038). When the level of serum EBV-DNA was < 4.0×102(copies/ml) or ≥ 4.0×102 (copies/ml), no significant difference was discovered in the OS rates among patients with different blood groups (P>0.05). Conclusion ABO blood group has no correlation with the occurrence, development and prognosis of NPC, and also has no significant association with Epstein-Barr virus infection.
熊海玉, 邓红玉, 钟沁安, 谢静, 欧阳淑娟. ABO血型与鼻咽癌发生发展及预后的相关性分析[J]. 实用预防医学, 2021, 28(11): 1303-1306.
XIONG Hai-yu, DENG Hong-yu, ZHONG Qin-an, XIE Jing, OUYANG Shu-juan. Correlation of ABO blood group with the occurrence, development and prognosis of nasopharyngeal carcinoma. , 2021, 28(11): 1303-1306.
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