Fluctuation of glutamic acid decarboxylase antibody positivity and its correlation with diabetes in general adult population
LI Jing1, LIN Song-bai1, DENG Chui-wen2
1. Department of Health Sciences, Peking Union Medical College Hospital, Beijing 100730, China; 2. Peking Union Medical College Hospital, Beijing 100730, China
Abstract：Objective To investigate the incidence rate of fluctuation of glutamic acid decarboxylase antibody (GADA) positivity and its clinical significance in general Chinese adults. Methods We searched the PUMCH-HM database for adult participants who had two or more GADA tests from 2014 to 2019. The changing status of GADA positivity and its association with diabetes were analyzed. Results A total of 5,736 participants were enrolled in this study. 50(0.9%)participants tested positive for GADA at least once, GADA positivity persisted in 12 participants and fluctuated in 38 ones. Of the 20 participants with positive GADA in the first test, 40% became negative. The GADA titers of persistent positive participants (85.5 (35.5, 835.0) IU/ml) were higher than those of fluctuant positive ones (12.9 (11.3, 15.0) IU/ml), with a statistically significant difference (P<0.001). The participants with GADA positive once had significantly lower body mass index, low-density lipoprotein cholestein, triglyceride and urine acid and higher high-density lipoprotein cholestein compared with those with persistent negative GADA, showing statistically significant differences. No statistically significant differences were found in the clinical indicators between persistent GADA positive group and fluctuant GADA positive group. Single factor and multivariable logistic regression analyses revealed that GADA positivity was not a risk factor for presence of diabetes. Male, increasing age, higher body mass index, higher triglyceride, lower high-density lipoproteincholestein,lower urine acid and hypertension were independent risk factors for presence of diabetes. Conclusion GADA positivity in general Chinese adults is far more likely to become negative. No significant differences are observed in the clinical indicators between persistent GADA positive group and fluctuant GADA positive group. GADA positivity may be not an independent risk factor for presence of diabetes.
李婧, 林松柏, 邓垂文. 普通成年人群抗谷氨酸脱羧酶抗体阳性波动性及其与糖尿病的相关性研究[J]. 实用预防医学, 2021, 28(11): 1299-1302.
LI Jing, LIN Song-bai, DENG Chui-wen. Fluctuation of glutamic acid decarboxylase antibody positivity and its correlation with diabetes in general adult population. , 2021, 28(11): 1299-1302.
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2021, Vol. 28 
