Etiological characteristics of strains from cases of epidemic cerebrospinal meningitis due to newly isolated Neisseria meningitidis serogroups X and Y in Hunan Province
Abstract：Objective To understand the drug susceptibility and molecular typing characteristics of strains from cases of epidemic cerebrospinal meningitis due to newly isolated Neisseria meningitidis serogroups X and Y in Hunan Province from 2019 to 2020. Methods Blood and cerebrospinal fluid specimens were collected from patients with epidemic cerebrospinal meningitis. Serogroups X and Y were identified and detected by culture and isolation, serological groups and susceptibility testing, multi-locus sequence typing (MLST). Results Serogroups X and Y strains were all sensitive to penicillin, ampicillin, minocycline,ceftriaxone, cefotaxime, chloramphenicol, azithromycin, meropenem and rifampicin in drug susceptibility test, but resistantto cotrimoxazole. Compared with serogroup B strains, the new strains were more sensitive to penicillin, ampicillin and fluoroquinolones. MLST results showed that strain X was the clone group of ST-5, and two strains of strain Y were the clone group of ST-23. Conclusion Serogroup X may be converted from serogroup A, while serogroup Y is consistent with the international highly pathogenic ST clone group. Both of them may become new epidemic serogroups and cause epidemic cerebrospinal meningitis outbreaks, which should be paid attention to.
夏昕, 方明礼, 覃迪, 贺子翔, 高立冬, 湛志飞. 湖南省新发X群Y群流行性脑脊髓膜炎病例菌株的病原学特征分析[J]. 实用预防医学, 2021, 28(11): 1295-1298.
XIA Xin, FANG Ming-li, QIN Di, HE Zi-xiang, GAO Li-dong, ZHAN Zhi-fei. Etiological characteristics of strains from cases of epidemic cerebrospinal meningitis due to newly isolated Neisseria meningitidis serogroups X and Y in Hunan Province. , 2021, 28(11): 1295-1298.
2021, Vol. 28 
