Expression of serum sTREM-1, TIMP-1 and NT-proBNP in patients with severe pneumonia and its correlation with their disease conditions and prognoses
BAI Bi-hui, CHEN Yu-si, SONG Ben-yan, ZHANG Yu-ling
Department of Respiratory and Critical Care Medicine, Panzhihua Hospital of Integrated Traditional Chinese and Western Medicine, Panzhihua, Sichuan 617000, China
Abstract：Objective To explore the expression of serum soluble triggering receptor expressed on myeloid cells-1(sTREM-1), tissue inhibitor of metalloproteinase-1 (TIMP-1) and N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with severe pneumonia and its correlation with the patients' disease condition and prognoses. Methods From June 2018 to February 2020, 84 patients with severe pneumonia from Panzhihua Hospital of Integrated Traditional Chinese and Western Medicine were selected as the severe group. During the same period, 84 patients with common pneumonia served as the ordinary group, and 84 healthy subjects were randomly selected as the control group. Serum levels of sTREM-1, TIMP-1 and NT-proBNP in the severe group and the ordinary group on the day of admission, the control group on the day of physical examination, and the severe group on the 3rd and 5th days of admission were detected and compared. The relationships of serum sTREM-1, TIMP-1 and NT-proBNP with the clinical pulmonary infection score (CPIS) and pneumonia severity index (PSI) score in the patients with severe pneumonia were explored. The general information of patients with different prognoses (survival or death) in the severe group and serum sTREM-1, TIMP-1 and NT-proBNP levels on the day of admission and the 3rd and 5th days of admission were compared. And the relationships among the expression of the serum indicators at each time point and prognoses and death of the patients with severe pneumonia, and the predictive values of the serum indicators for prognoses and death of the patients with severe pneumonia were explored. Results Serum sTREM-1, TIMP-1 and NT-proBNP levels on the day of admission were higher in the severe group than in the ordinary group (P<0.05) as well as higher in the ordinary group than in the control group (P<0.05). CPIS score and PSI score of the patients with severe pneumonia were positively correlated with serum sTREM-1, TIMP-1 and NT-proBNP on the day of admission (P<0.05). The CPIS score and PSI score of death patients in the severe group were higher than those of survival patients. The expression of serum sTREM-1, TIMP-1 and NT-proBNP was higher in the patients who died on the day of admission and the 3rd and 5th day of admission than in the survival patients (P<0.05). The area under the curve (AUC) of serum sTREM-1, TIMP-1 and NT-proBNP levels on the 5th day of admission to predict the prognoses and death in patients with severe pneumonia were all above 0.7, and the prediction effect was good, especially the AUC predictedbased on combined indexes was as high as 0.916, with the best prediction sensitivity and specificity of 80.00% and 91.53%, respectively. Conclusion Serum sTREM-1, TIMP-1 and NT-proBNP levels in the patients with severe pneumonia significantly increased, which were closely related to the patients' disease conditions. Detecting the above-mentioned serum indicators when the severe pneumonia patients are admitted to the hospital can help doctors assess the risk of death.
白碧慧, 陈余思, 宋本艳, 张榆铃. 重症肺炎患者血清sTREM-1、TIMP-1、NT-proBNP表达及与其病情、预后的关联性[J]. 实用预防医学, 2021, 28(8): 956-960.
BAI Bi-hui, CHEN Yu-si, SONG Ben-yan, ZHANG Yu-ling. Expression of serum sTREM-1, TIMP-1 and NT-proBNP in patients with severe pneumonia and its correlation with their disease conditions and prognoses. , 2021, 28(8): 956-960.
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2021, Vol. 28 
