摘要目的 分析2012—2019年深圳队列调查研究的男男性行为者(men who have sex with men, MSM)梅毒感染情况,为降低本地区该人群梅毒感染率开展有效的干预措施提供数据参考。 方法 以2012—2019年深圳MSM不同队列调查研究如时空场所抽样(time-location sampling, TLS)、同伴推动抽样(respondent driven sampling, RDS)、自愿咨询检测门诊抽样(voluntary counseling and testing, VCT)、跨境人群调查、阴性人群随访等研究对象,采集静脉血进行梅毒抗体筛查检测。使用χ2检验和二分类logistic回归对MSM的梅毒感染率进行单因素和多因素统计学分析。 结果 2012—2019年共检测MSM 20 358例,平均年龄(28.99±7.94)岁,梅毒抗体总检出阳性率为13.4%。2012年MSM梅毒的感染率最高为19.3%,其后逐年呈先下降后上升趋势,各年份之间的梅毒感染率差异有统计学意义(χ2趋势=119.05,P<0.001)。≥50岁的MSM人群梅毒感染率为最高(33.6%),<20岁的为最低(7.8%),而30~岁、40~岁、≥50岁各年龄段和<20岁的梅毒感染率有显著性差异(P值均<0.001)。跨境人群调查MSM的梅毒感染率为最高(21.4%);阴性人群随访、RDS和VCT的感染率较高,分别为15.4%、14.2%和14.1%;TLS的感染率为最低(11.6%)。VCT的感染率是TLS的1.240倍(P值<0.001),RDS、阴性人群随访和跨境人群调查感染率分别是TLS的1.158,1.209,2.023倍(P值均<0.05)。在TLS人群中,有商业性行为的感染率(5.0%)低于无商业性行为的(18.3%)(χ2=347.73,P<0.001)。 结论 2012—2019年深圳市MSM人群梅毒感染率呈逐年下降趋势,TLS调查的梅毒感染率较低,>40岁组阳性病例占比上升明显,应重点关注>40岁MSM人群的梅毒防控。
Abstract:Objective To analyze the status of syphilis infection in the cohort investigation among men who have sex with men (MSM) in Shenzhen from 2012 to 2019, and to provide data references for taking effective intervention measures to reduce syphilis infection rate in this population in this region. Methods We selected MSM in different cohort surveys, including time-location sampling (TLS), respondent-driven sampling (RDS), voluntary counseling and testing (VCT) outpatient sampling, cross-border population survey and follow-up of negative population, in Shenzhen during 2012-2019 to serve as the research subjects. Venous blood was collected for syphilis antibody screening test. Univariate and multivariate statistical analyses were performed for syphilis infection rate of MSM by chi-squared test and dichotomous logistic regression. Results A total of 20,358 MSM were detected from 2012 to 2019, and the average age was (28.99±7.94) years, with the total positive rate of syphilis antibody being 13.4%. The highest infection rate of syphilis in the MSM in 2012 was 19.3%, thereafter the infection rate decreased firstly and then increased year by year, with statistically significant differences in the infection rates of syphilis among different years (χ2trend=119.05, P<0.001). The syphilis infection rate was found to be the highest among MSM aged 50 years or above (33.6%), but the lowest among MSM aged 20 years or below (7.8%). There were statistically significant differences in the syphilis infection rates among MSM aged 30- years, 40- years, 50 years or above, and less than 20 years (all P<0.001). The syphilis infection rate of MSM in cross border population was the highest (21.4%), followed by the negative population (15.4%), RDS (14.2%) and VCT (14.1%). The syphilis infection rate of MSM in TLS was the lowest (11.6%). The syphilis infection rate in VCT population was 1.240 times that in TLS population (P<0.001). Compared with TLS population, the syphilis infection rates in RDS, negative population, cross border population were 1.158, 1.209 and 2.023 times, respectively (all P<0.05). Among TLS population, the infection rate was lower in MSM with commercial sex than in MSM without commercial sex (5.0% vs. 18.3%, χ2=347.73, P<0.001). Conclusion The syphilis infection rate of MSM is Shenzhen during 2012-2019 showed a downward trend year by year. The syphilis infection rate of MSM surveyed by TLS was relatively low. The proportion of positive cases in MSM aged over 40 years increased significantly. Therefore, special attention should be paid to MSM aged over 40 years in syphilis prevention and control.
甘永霞, 李浩, 赵锦, 黎桂连, 谭唯, 石向东, 王晓辉, 杨峥嵘. 2012—2019年深圳男男性行为者不同队列调查的梅毒感染情况分析[J]. 实用预防医学, 2021, 28(7): 822-825.
GAN Yong-xia, LI Hao, ZHAO Jin, LI Gui-lian, TAN Wei, SHI Xiang-dong, WANG Xiao-hui, YANG Zheng-rong. Analysis of syphilis infection status in different cohort surveys among MSM in Shenzhen, 2012-2019. , 2021, 28(7): 822-825.
[1] 陈祥生.我国梅毒防治面临的挑战和对策[J]. 国际流行病学传染病学杂志,2020, 47(4):289-292. [2] 何婉苹,叶兴东,汤少开,等. 广州市男男性接触者人群HIV和梅毒感染及相关因素调查研究[J]. 中国预防医学杂志, 2015, 16(9):684-688. [3] 谭唯,刘少础,赵锦,等. 深圳市HIV/AIDS病例经异性性传播方式分析[J]. 实用预防医学, 2019, 26(12):1409-1411. [4] 高慧,肖芙蓉,许小珍,等. 男男性行为艾滋病毒感染者梅毒感染的影响因素分析[J]. 中国性科学, 2016, 25(10):91-95. [5] Zhao J, Cai R, Chen L, et al. A comparison between respondent-driven sampling and time-location sampling among men who have sex with men in Shenzhen, China[J]. Arch Sex Behav,2015,44(7):2055-2065. [6] 黄勤,李巧巧,李苑,等. 2010—2013年中国男男性行为艾滋病/梅毒感染状况、性行为特征及艾滋病知识知晓情况的meta分析[J]. 中华流行病学,2015,26(11):1297-1304. [7] 邱英鹏,刘爱忠,冯铁建,等.中国大陆MSM人群HIV/梅毒感染状况性行为特征和艾滋病知识知晓情况的Meta分析 [J]. 中国艾滋病性病,2013,19(3):169-173. [8] 叶兴东,汤少开,何婉苹,等. 广州地区男男性行为者梅毒感染率及危险因素分析[J]. 中国艾滋病性病, 2016, 22(11):921-925. [9] 齐金蕾,张大鹏,付晓静,等.不同招募途径的男男性行为人群梅毒感染状况及影响因素分析[J].中华预防医学杂志,2015,49(5):399-404. [10] 刘瑛,唐海丰,宁镇,等.上海市艾滋病自愿咨询检测门诊男男性行为者HIV与梅毒、单纯疱疹病毒2型共感染状况调查[J].中华流行病学杂志,2017,38(10):1363-1366. [11] 管文辉,朱银霞,魏庆,等. 南京市2008—2013年男男性行为人群早期梅毒及HIV感染率变化趋势分析[J]. 中华流行病学杂志,2015,36(6):624-628. [12] 高洁,傅卓华,赵秀萍,等. 苏州市男男性行为者梅毒感染状况及影响因素研究[J]. 中国艾滋病性病, 2019, 25(4):392-394. [13] 李艳,林鹏,付笑冰,等. 几种抽样方法在社区暗娼人群艾滋病调查中的应用[J]. 公共卫生与预防医学,2011,22(6):15-18. [14] 蔡于茂,宋亚娟,刘惠,等. 2011—2016年深圳市男男性行为人群梅毒和HIV感染情况及影响因素[J]. 中华预防医学杂志,2017,51(11):994-1000. [15] Li D, Li C, Wang Z, et al. Prevalence and associated factors of unprotected anal intercourse with regular male sex partners among HIV negative men who have sex with men in China: across-sectional survey[J]. PLoS One,2015,10(3):e0119977. [16] 肖岳姣,刘少础,谢炜,等. 深圳市场所中男男性行为者HIV感染情况及影响因素调查[J]. 中国艾滋病性病, 2020, 26(8):871-873. [17] 贾飞飞,路丕国. 青岛市某高校大一新生艾滋病知信行现状调查与分析[J]. 中国艾滋病性病, 2018, 24(3):295-298. [18] 吴梦瑶,张韬.我国大学生艾滋病知信行和健康教育的研究现状综述[J]. 预防医学情报杂志, 2019, 35(12):1341-1346. [19] 周艳秋,顾凯侃,孙利敏,等. 上海市50岁以上MSM人群HIV和梅毒的感染率及影响因素[J]. 中国健康教育, 2015,31(5):473-478. [20] 周彤,姜珍霞,傅泳,等. 青岛市2010—2017年梅毒流行趋势及高危人群梅毒流行情况分析[J]. 中国麻风皮肤病杂志,2020,36(1):28-31.