Correlation of hemoglobin and hematocrit with hypertension in middle-aged and elderly people in Guangzhou
ZHOU Bai-jing1, ZHANG Wei-sen2, XU Lin3, JIN Ya-li2, ZHU Tong2, ZHU Feng2, JIANG Chao-qiang2, LIN Da-Qing4
1. Molecular Epidemiology Research Center, the Twelfth Hospital Affiliated to Guangzhou Medical University,Guangzhou, Guangdong 510620, China; 2. The Twelfth People’s Hospital of Guangzhou, Guangzhou, Guangdong 510620, China; 3. School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong 510080, China; 4. School of Public Health, the University of Hong Kong, Hong Kong 999077, China
Abstract：Objective To analyze the correlation of hemoglobin (HGB) and hematocrit (HCT) with hypertension in the middle-aged and elderly so as to provide scientific references for prevention and control of hypertension risk from increased blood viscosity. Methods Based on the platform of Guangzhou Biobank Cohort Study (GBCS), 24,944 Guangzhou residents aged 50 years and above and without Cooley’s anemia were selected, and data including age, gender, educational background,occupation, personal income, smoking, drinking, physical activity, body mass index (BMI), fasting total cholesterol (TC),triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and blood glucose were collected through the baseline survey. Logistic regression model was used to analyze the association of HGB and HCT with hypertension among the residents with different genders. Results Male residents accounted for 28.6% in this study, and their mean age ((64.3±6.7) years) was greater than that of female ones ((61.3±7.0) years). The prevalence rate of hypertension was 49.3% in male residents and 46.2% in female ones, and the prevalence rates of hypertension in the male and female residents both increased with the increasing HGB and HCT levels (P<0.001).Compared with the non-hypertension group, residents in the hypertension group had elder age and higher HGB and HCT levels (all P<0.001). After adjusting for relevant confounders above, comparing with the first quartile, residents at the fourth quartile of HGB and HCT showed the highest odds ratio of hypertension, with ORs(95%CI) being 1.35(1.16-1.57), 1.29(1.11-1.50) in males and 1.51 (1.37-1.67), 1.47 (1.34-1.61) in females, respectively (all P<0.001). Conclusion The elevated levels of HGB and HCT in the middle-aged and elderly are associated with a higher risk of hypertension. It is suggested that appropriate attention should be paid to the risk of hypertension associated with increased blood viscosity caused by abnormal increase in HGB and HCT among middle-aged and elderly people
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2021, Vol. 28 
