血栓易感基因多态性与习惯性流产的关系研究进展

doi:10.3969/j.issn.1006-3110.2021.05.027

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摘要习惯性流产是全球严重的生殖健康问题之一,影响育龄妇女的身心健康、家庭和谐。抗凝和凝血机制之间平衡可保证胎儿与母体之间血液循环,维持正常妊娠。近年来研究发现血栓易感基因多态性的发生可增加血液循环障碍风险,并导致流产。了解两者之间关系的研究进展,以期为相关研究提供依据,更好的预防和治疗习惯性流产,促进母婴健康。

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	周青
	刘帅妹
	张瑞金
	石慧
	林宁
	吴玉璘

关键词 ：习惯性流产, 血液循环, 血栓, 基因多态性

Abstract：Recurrent spontaneous abortion is one of the serious reproductive health problems in the world, affecting the physical and mental health of women of childbearing age and the harmoniousness of families. The balance between anticoagulation and coagulation mechanisms can ensure blood circulation between the fetus and the mother and maintain normal pregnancy. In recent years, studies have found that the occurrence of thrombotic susceptibility gene polymorphisms can increase the risk of blood circulation disorder and lead to abortion. Understanding the research progress on the relationship between the two is conductive to providing a basis for future in-depth research, better preventing and treating recurrent spontaneous abortion and promoting maternal and child health.

Key words： recurrent spontaneous abortion blood circulation thrombus gene polymorphism

收稿日期: 2020-07-05

R714.4

基金资助:江苏省科技厅项目( BM2018033-3);江苏省计划生育科学技术研究所自主科研项目(JSFP-2018003)

通讯作者: 吴玉磷,E-mail:wylnj@126.com。

作者简介: 周青(1990-),女,江苏东台人,硕士研究生,助理研究员,主要从事分子生物学研究工作。

引用本文:

周青, 刘帅妹, 张瑞金, 石慧, 林宁, 吴玉璘. 血栓易感基因多态性与习惯性流产的关系研究进展[J]. 实用预防医学, 2021, 28(5): 638-641. ZHOU Qing, LIU Shuai-mei, ZHANG Rui-jin, SHI Hui, LIN Ning, WU Yu-lin. Research progress on the relationship between thrombotic susceptibilitygene polymorphism and recurrent spontaneous abortion. , 2021, 28(5): 638-641.

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