Pathogen distribution and drug resistance of long-term hospitalized senile patientswith lower respiratory tract infection
HUANG Hong-lin, YI Bin
Department of Clinical Laboratory, Xiangya Hospital of Central South University, Changsha, Hunan 410008, China Corresponding author: YI Bin, E-mai:E-mail:171193131@qq.com
Abstract：Objective To analyze the pathogen distribution and drug resistance characteristics in long-term hospitalized senile patients with lower respiratory tract infection so as to provide evidence for clinical diagnosis and rational use of antibiotics. Methods We retrospectively analyzed the results of bacteria culture and drug sensitivity test of 910 lower respiratory tract specimens from long-term hospitalized senile patients in Xiangya Hospital from July 2014 to June 2015. Results A total of 1,315 strains of bacteria were isolated from the 910 specimens, of which 1,073 (81.60%) strains were gram-negative bacilli and most of them were Pseudomonas aeruginosa, Klebsiella pneumoniae, Acinetobacter baumannii and Escherichia coli. There were 61(4.64%) strains of gram-positive cocci and most of them were Staphylococcus aureus. 177 (13.46%) strains of fungi were isolated, and the isolation rate of Candida albicans was predominant. The others accounted for 0.30% (4/1,315). 396 (43.52%) specimens were infected with more than 2 kinds of pathogens. The resistance rates of Pseudomonas aeruginosa to most antibiotics were above 30.00%, with the resistance rate to meropenem being 38.70%. Acinetobacter baumannii showed high resistance rates to all kinds of antibiotics, and its resistance rate to meropenem reached 76.50%. The resistance rate of Klebsiella pneumoniae to meropenem was 19.42%. Among the isolated gram-positive cocci, methicillin-resistant Staphylococcus aureus accounted for 60.00%. Vancomycin, linezolid and teicoplanin had good antibacterial activity against Staphylococcus aureus, and no resistant strains were found. Conclusions Gram-negative bacilli are the major pathogens isolated from long-term hospitalized senile patients with lower respiratory tract infection and their drug resistance is serious, so it is significant to select appropriate antibiotics according to the results of drug sensitivity tests.
2017, Vol. 24 
