Abstract:Objective To explore the relationship of hyperuricemia with the risk of cardiovascular disease mortality in a cohort of patients with type 2 diabetes mellitus (T2DM). Methods All participants were selected from a cohort study of T2DM patients in Changshu City, Jiangsu Province. Multivariate Cox regression models were used to analyze the hazard ratio (HR) and 95% confidence interval (CI) of cardiovascular disease mortality in T2DM patients with different baseline levels of uric acid. Results Among the 10,246 T2DM patients, follow-ups were accumulatively conducted in 59,032.86 person-years. The median of follow-ups was 6 years, and 260 patients died of cardiovascular disease during the follow-ups. After adjusting for potential confounding factors, the hazard ratio (95% confidence interval) of cardiovascular disease mortality in the hyperuricemia group was 1.753 (1.299-2.366) compared with the baseline normal uric acid group. In the groups with male patients, with female patients, aged ≤60 years, aged >60 years, without central obesity, with normal blood lipid, with dyslipidemia and hypertension, compared with the normal uric acid group, the hyperuricemia group increased the risk of death from cardiovascular disease in the T2DM patients, with statistically significant differences (HR=1.780,HR=1.756,HR=5.583,HR=2.065,HR=1.964,HR=1.705,HR=1.579,HR=1.748, all P<0.05). After excluding patients with cardiovascular disease and kidney disease at baseline, the remaining 8,686 patients with T2DM underwent sensitivity analysis. Compared with the baseline normal uric acid group, the HR (95%CI) of cardiovascular mortality in the hyperuricemia group was 1.250 (1.043-1.498). Conclusion Hyperuricemia is independently associated with increased cardiovascular disease mortality risk in patients with T2DM.
顾淑君, 张秋伊, 周正元. 2型糖尿病人群中高尿酸血症与心血管病死亡风险的队列研究[J]. 实用预防医学, 2021, 28(4): 435-438.
GU Shu-jun, ZHANG Qiu-yi, ZHOU Zheng-yuan. Cohort study on hyperuricemia and the risk of cardiovascular disease mortality in patients with type 2 diabetes mellitus. , 2021, 28(4): 435-438.