Abstract:Objective To quantitatively study the correlation between deaths due to respiratory diseases and tobacco exposure in population so as to provide a scientific basis for tobacco prevention and control. Methods Data from the database concerning monitoring of chronic diseases and their risk factors in 2015 were used as the baseline data. We actively performed follow-up of respiratory diseases and related general information among people over 40 years old in Cixi region, Zhejiang Province from 2016 to 2019. Attribution analysis and Cox proportional hazard model were used for statistical correlation analysis, and the population attributable risk percent (PAR%) and the hazard ratio (HR) of the tobacco-exposed population were obtained. Results From 2016 to 2019, the total mortality rate of respiratory diseases in Cixi, Zhejiang was 117.96/100,000, and the mortality rate was higher in males (148.86/100,000) than in females (87.07/100,000), showing a statistically significant difference (P=0.015). Among the diseases of respiratory system, PAR% of chronic obstructive pulmonary diseases (COPD) was 69.48% which was higher than those of other chronic respiratory diseases. The deaths from COPD and lower respiratory infections were positively correlated with tobacco exposure (P<0.05). Among the group aged 50-59 years, the risk of death in COPD increased by 13% for each 10-year increase in smoking index (HR=1.13, 95%CI: 1.08-1.24), and the risk of death in lower respiratory infections increased by 20% (HR=1.20, 95%CI:1.03-1.23). Conclusions Smoking is one of the main risk factors for the burden of respiratory diseases. Tobacco exposure has a clear correlation with death from respiratory diseases. The attributable risk percentage of COPD is the highest and should be given sufficient attention. The sensitivities of hazards from tobacco exposure among different gender and age populations are dissimilar; and hence, tobacco control work should be targeted.
戴晓, 董志君. 2016—2019年慈溪地区40岁以上人群呼吸系统疾病死亡与烟草暴露的相关性分析[J]. 实用预防医学, 2021, 28(1): 15-19.
DAI Xiao, DONG Zhi-jun. Correlation between deaths from respiratory diseases and tobacco exposure in people over 40 years old in Cixi region, 2016-2019. , 2021, 28(1): 15-19.
[1] Georgiopoulos G,Oikonomou D,Pateras K, et al. A bayesian meta-analysis on early tobacco exposure and vascular health: from childhood to early adulthood[J]. Eur J Prev Cardiol,2019,32(8):85-89. [2] Viarisio D,Robitaille A,Müller-Decker K,et al. Cancer susceptibility of beta HPV49 E6 and E7 transgenic mice to4-nitroquinoline 1-oxide treatment correlates with mutational signatures of tobacco exposure[J]. Virology,2019, 538(2):53-60. [3] 赵超,杨国,刘起展. 中学生吸烟干预效果分析[J]. 实用预防医学,2019,26(1):99-101. [4] 楼宏青,姚炯,嵇水玉,等. 浙江中北部农村男性居民吸烟状态与慢性肾脏病患病的现状调查[J]. 健康研究,2018,38(5):481-484. [5] Zhou M, Wang H, Zeng X, et al. Mortality, morbidity, and risk factors in China and its provinces, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017[J]. Lancet,2019,394(10):1145-1158. [6] Duarte G, Williams CJ, Vasconcelos P, et al. Capacity to report on mortality attributable to chronic hepatitis B and C infections by Member States: an exercise to monitor progress towards viral hepatitis elimination[J].J Viral Hepat, 2018,25(7):878-882. [7] Whitehead J. Fitting Cox's regression model to survival data using glim[J]. J Applied Stat, 1980, 29(3):268-275. [8] Kemnade JO, Elhalawani H, Castro P,et al. CD8 infiltration is associated with disease control and tobacco exposure in intermediate-risk oropharyngeal cancer[J]. Sci Rep,2020,10(1):243. [9] Osorio-Yanez C, Clemente D, Maitre L, et al. Early life tobacco exposure and children's telomere length: the HELIX project[J]. Sci Total Environ,2020,7(11):135-138. [10] Moore PJ, Sesma J, Alexis NE, et al. Tobacco exposure inhibits SPLUNC1-dependent antimicrobial activity[J]. Respir Res,2019,20(1):94. [11] 王洪斌, 邓超, 蔡兴俊. 烟草烟雾暴露对哮喘小鼠肺组织NF-KB p65表达的影响[J].中国热带医学,2019,19(11):1018-1021. [12] Ben FM, Mrad DK, Kallel A, et al. Interaction effects of plasma vitamins A, E, D, B9, and B12 and tobacco exposure in urothelial bladder cancer: a multifactor dimensionality reduction analysis[J]. Nutr Cancer,2019,71(8):1382-1389. [13] Dong YM, Qin LD, Tong YF, et al. Multiple genome pattern analysis and signature gene identification for the Caucasian lung adenocarcinoma patients with different tobacco exposure patterns[J]. Peer J,2020,32(8):83-89. [14] Khalifeh M, Hobeika R, El HL, et al. Nicotine induces resilience to chronic social defeat stress in a mouse model of water pipe tobacco exposure by activating BDNF signaling[J]. Behav Brain Res,2020,38(2):112-119. [15] Shenoy RD, Sindgikar SP, Shenoy V, et al. Pregnancy outcome in occupational tobacco exposure: a cohort study from south india[J]. Indian J Community Med,2020,45(1):54-59. [16] Shahab L, Goniewicz ML, Blount BC, et al. Nicotine, carcinogen, and toxin exposure in long-term E-cigarette and nicotine replacement therapy users: a cross-sectional study[J]. Ann Intern Med,2017,166(6):390-400. [17] 王荀,廖玉学,刘丽红,等. 深圳市龙岗区大气污染物与医院呼吸系统疾病门诊量的广义相加模型分析[J]. 实用预防医学,2019,26(1):65-68. [18] Collins BN, Lepore SJ, Winickoff JP, et al. Parents' self-efficacy for tobacco exposure protection and smoking abstinence mediate treatment effects on child cotinine at 12-month follow-up: mediation results from the kids safe and smokefree trial[J]. Nicotine Tob Res,2019,34(3):35-39. [19] Minatoya M, Araki A, Itoh S, et al. Prenatal tobacco exposure and ADHD symptoms at pre-school age: the Hokkaido Study on Environment and Children's Health[J]. Environ Health Prev Med,2019,24(1):74. [20] Groot J,Nybo AA,Blegvad C,et al. Prenatal, infantile, and childhood tobacco exposure and risk of pediatric psoriasis in the Danish National Birth Cohort offspring[J]. J Am Acad Dermatol,2020,12(4):123-128.