Abstract:The incidence rate of gestational diabetes mellitus show an upward tendency at present; moreover, it leads to many adverse pregnancy outcomes in pregnant women and perinatal children. Researches show that excessive iron intake in the human body may cause gestational diabetes mellitus, but there is no definite conclusion. Therefore, this paper outlines the characteristics of different types of iron and their correlation with gestational diabetes mellitus. By summarizing the current relevant studies, this paper explores the shortcomings and deficiencies of the researches, and provides a scientific basis for prevention and control of gestational diabetes mellitus.
孙策, 纪超, 吴琪俊, 赵玉虹. 孕期铁摄入与妊娠期糖尿病发病风险的研究进展[J]. 实用预防医学, 2020, 27(12): 1540-1544.
SUN Ce, JI Chao, WU Qi-jun, ZHAO Yu-hong. Research progress on iron intake in pregnancy and risk for onset of gestational diabetes mellitus. , 2020, 27(12): 1540-1544.
[1] American Diabetes Association. Diagnosis and classification of diabetes mellitus[J]. Diabetes Care, 2009,32 (Suppl 1):S62-S67. [2] 关怀, 尚丽新. 妊娠期糖尿病流行现状[J]. 中国实用妇科与产科杂志, 2015,31(1):91-94. [3] Kataria Y, Wu Y, Horskjaer PH, et al. Iron status and gestational diabetes-A meta-analysis[J]. Nutrients, 2018,10(5):333-348. [4] 杨幼林, 赵荷兰, 安利红, 等. 妊娠期糖尿病产妇产后糖尿病发生情况及危险因素研究[J]. 实用预防医学, 2017,24(6):696-698. [5] Waters TP, Dyer AR, Scholtens DM, et al. Maternal and neonatal morbidity for women who would be added to the diagnosis of GDM using IADPSG criteria: a secondary analysis of the hyperglycemia and adverse pregnancy outcome study[J]. Diabetes Care, 2016,39(12):2204-2210. [6] Boghossian NS, Yeung E, Albert PS, et al. Changes in diabetes status between pregnancies and impact on subsequent newborn outcomes[J]. Am J Obstet Gynecol, 2014,210(5):431. [7] Gavin J, Alberti K, Davidson M, et al. Report of the expert committee on the diagnosis and classification of diabetes mellitus[J]. Diabetes Care, 1997,20(7):1183. [8] Kim SY, England L, Wilson HG, et al. Percentage of gestational diabetes mellitus attributable to overweight and obesity[J]. Am J Public Health, 2010,100(6):1047-1052. [9] Bah A, Wegmuller R, Cerami C, et al. A double blind randomised controlled trial comparing standard dose of iron supplementation for pregnant women with two screen-and-treat approaches using hepcidin as a biomarker for ready and safe to receive iron[J]. BMC Pregnancy Childbirth, 2016,16(1):157. [10] Lambing A, Kachalsky E, Mueller ML. The dangers of iron overload: bring in the iron police[J]. J Am Acad Nurse Pract, 2012,24(4):175-183. [11] 顾伊丽, 邵宗鸿. 铁负荷过载研究进展及治疗[J]. 中国实用内科杂志, 2010,30(12):1141-1142. [12] Liu XN, Liu PY. The effectiveness of weekly iron supplementation regimen in improving the iron status of Chinese children and pregnant women[J]. Biomed Environ Sci, 1996,9(2-3):341-347. [13] 钟才云,马凤楼. 血红素铁的生物利用研究[J]. 营养学报, 1989, 11(2):135-140. [14] Milman N. Iron in pregnancy: How do we secure an appropriate iron status in the mother and child?[J]. Ann Nutr Metab, 2011,59(1):50-54. [15] Darling AM, Mitchell AA, Werler MM. Preconceptional iron intake and gestational diabetes mellitus[J]. Int J Environ Res Public Health, 2016,13(6). [16] Bo S, Menato G, Villois P, et al. Iron supplementation and gestational diabetes in midpregnancy[J]. Am J Obstet Gynecol, 2009,201(2):151-158. [17] Bowers K, Yeung E, Williams MA, et al. A prospective study of prepregnancy dietary iron intake and risk for gestational diabetes mellitus[J]. Diabetes Care, 2011,34(7):1557-1563. [18] Chen X, Scholl TO, Stein TP. Association of elevated serum ferritin levels and the risk of gestational diabetes mellitus in pregnant women: the Camden study[J]. Diabetes Care, 2006,29(5):1077-1082. [19] 吴斌,游开绍. 血红素铁防治缺铁性贫血研究[J]. 海峡药学, 1997, 9(1):130-131. [20] Reizenstein P. Heme and non-heme iron in the prevention and treatment of iron deficiency anemia[J]. Nord Med, 1988,103(4):130-131. [21] Mari-Sanchis A, Diaz-Jurado G, Basterra-Gortari FJ, et al. Association between pre-pregnancy consumption of meat, iron intake, and the risk of gestational diabetes: the SUN project[J]. Eur J Nutr, 2018,57(3):939-949. [22] Qiu C, Zhang C, Gelaye B, et al. Gestational diabetes mellitus in relation to maternal dietary heme iron and nonheme iron intake[J]. Diabetes Care, 2011,34(7):1564-1569. [23] Fu S, Li F, Zhou J, et al. The relationship between body iron status, iron intake and gestational diabetes: a systematic review and meta-analysis[J]. Medicine (Baltimore), 2016,95(2):e2383. [24] Zhang C, Rawal S. Dietary iron intake, iron status, and gestational diabetes[J]. Am J Clinytr, 2017,106(Suppl 6):1672S-1680S. [25] Frazer DM, Anderson GJ. Iron imports. I. Intestinal iron absorption and its regulation[J].Am J Physiol Gastrointest Liver Physiol, 2005,289(4):631-635. [26] Zhang C, Schulze MB, Solomon CG, et al. A prospective study of dietary patterns, meat intake and the risk of gestational diabetes mellitus[J]. Diabetologia, 2006,49(11):2604-2613. [27] Milman N. Oral iron prophylaxis in pregnancy: not too little and not too much[J]. J Pregnancy, 2012,2012:514345. [28] Stephansson O, Dickman PW, Johansson A, et al. Maternal hemoglobin concentration during pregnancy and risk of stillbirth[J]. JAMA, 2000,284(20):2611-2617. [29] Huisman A, Aarnoudse JG. Increased 2nd trimester hemoglobin concentration in pregnancies later complicated by hypertension and growth retardation. Early evidence of a reduced plasma volume[J]. Acta Obstet Gynecol Scand, 1986,65(6):605-608. [30] Steer P, Alam MA, Wadsworth J, et al. Relation between maternal haemoglobin concentration and birth weight in different ethnic groups[J]. BMJ, 1995,310(6978):489-491. [31] Chan KK, Chan BC, Lam KF, et al. Iron supplement in pregnancy and development of gestational diabetes--a randomised placebo-controlled trial[J]. BJOG, 2009,116(6):789-798. [32] Zhu B, Liang C, Xia X, et al. Iron-related factors in early pregnancy and subsequent risk of gestational diabetes mellitus: the Ma'anshan Birth Cohort (MABC) Study[J]. Biol Trace Elem Res, 2018, 191(1):45-53. [33] Helin A, Kinnunen TI, Raitanen J, et al. Iron intake, haemoglobin and risk of gestational diabetes: a prospective cohort study[J]. BMJ Open, 2012,2(5):185-196. [34] Buchanan TA, Xiang A, Kjos SL, et al. What is gestational diabetes? [J]. Diabetes Care, 2007,30 (Suppl 2):S105-S111. [35] Liu Q, Sun LY, Wang G, et al. Role of iron deficiency and overload in the pathogenesis of diabetes and diabetic complications[J]. Curr Med Chem, 2009,16(1):113-129. [36] Torti FM, Torti SV. Regulation of ferritin genes and protein[J]. Blood, 2002,99(10):3505-3516. [37] Mandato C, Lucariello S, Licenziati MR, et al. Metabolic, hormonal, oxidative, and inflammatory factors in pediatric obesity-related liver disease[J]. J Pediatr, 2005,147(1):62-66. [38] Sacks GP, Seyani L, Lavery S, et al. Maternal C-reactive protein levels are raised at 4 weeks gestation[J]. Hum Reprod, 2004,19(4):1025-1030. [39] Retnakaran R, Hanley AJ, Raif N, et al. C-reactive protein and gestational diabetes: the central role of maternal obesity[J]. J Clin Endocrinol Metab, 2003,88(8):3507-3512. [40] Kriketos AD, Greenfield JR, Peake PW, et al. Inflammation, insulin resistance, and adiposity:a study of first-degree relatives of type 2 diabetic subjects[J]. Diabetes Care, 2004,27(8):2033-2040. [41] Wolf M, Sandler L, Hsu K, et al. First-trimester C-reactive protein and subsequent gestational diabetes[J]. Diabetes Care, 2003,26(3):819-824. [42] Qiu C, Sorensen TK, Luthy DA, et al. A prospective study of maternal serum C-reactive protein (CRP) concentrations and risk of gestational diabetes mellitus[J]. Paediatr Perinat Epidemiol, 2004,18(5):377-384. [43] Rohner F, Namaste SM, Larson LM, et al. Adjusting soluble transferrin receptor concentrations for inflammation: biomarkers reflecting inflammation and nutritional determinants of anemia (BRINDA) project[J]. Am J Clin Nutr, 2017,106(Suppl 1):372S-382S. [44] Tarim E, Kilicdag E, Bagis T, et al. High maternal hemoglobin and ferritin values as risk factors for gestational diabetes[J]. Int J Gynaecol Obstet, 2004,84(3):259-261. [45] Knowles J, Thurnham DI, Phengdy B, et al. Impact of inflammation on the biomarkers of iron status in a cross-sectional survey of lao women and children[J]. Br J Nutr, 2013,110(12):2285-2297.