Abstract:Objective To investigate the prevalence rates of hyperuricemia (HUA) and gout in residents in the ZhoushanArchipelago, and to explore the risk factors of HUA. Methods A study was carried out in population who had physical examination in the Health Guidance Center of Zhoushan Hospital from July 2016 to June 2017. The prevalence rates of HUA and gout in 5,745 adults were investigated. Results The prevalence rate of HUA was 23.2%, and the standardized rate was 20.4%, of which the prevalence rates in males and females were 13.0% and 38.8%, respectively. The prevalence rate of gout was 1.9%, and the standardized rate was 2.0%, of which the prevalence rates in males and females were 2.7% and 0.8%, respectively. The prevalence rate of gout in patients with HUA was 1.7%. The average level of serum uric acid was (341.1±71.4) umol/L, with (350.0±78.3) umol/L in males and (327.4±56.5) umol/L in females. Age and levels of blood pressure, blood sugar, serum uric acid and triglyceride were significantly higher in the gout group than in the normal group (all P<0.05). Levels of blood pressure, blood sugar, serum uric acid and total cholesterol were significantly higher in the HUA group than in the normal group (all P<0.05). Creatinine clearance rate was lower in the gout group and the HUA group than in the normal group (both P<0.05). Logistic multivariate regression analysis showed that blood pressure, hyperlipidemia and abnormal renal function were risk factors for HUA.Conclusions The prevalence rates of HUA and gout in residents in the Zhoushan Archipelago are high, especially in women, which is significantly higher than those in other parts of China. Corresponding countermeasures should be taken to reduce the prevalence rates of HUA and gout in the residents.