1. Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention, Nanning, Guangxi 530028, China; 2. State Key Laboratory of Infectious Disease Prevention and Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China
Abstract：Objective To understand the situation and related influencing factors of sero-positive partners failing to receive antiretroviral therapy (ART) in HIV-1 sero-discordant couples in Guangxi from 2012 to 2017. Methods Data were collected from the National Basic Information System for HIV/AIDS Prevention and Control. Retrospective study method and cause-specific Cox proportional hazard models were used to analyze the situation of sero-positive partners or fixed sexual partners receiving ART and the factors affecting them failing to receive ART in HIV-1 sero-discordant couples in Guangxi during 2012-2017. Results A total of 13,191 cases were enrolled in this study as of December 31, 2017, and the rate of receiving ART in sero-positive partners or fixed sexual partners in HIV-1 sero-discordant couples was 86.65 per 100 person-years. Results from Cox proportional hazard models revealed that the related factors and AHRs for ART rate appeared as:HIV positive confirmation in 2013-2017 (vs. 2012, AHR=1.17-1.54, 95%CI:1.09-1.65), females (vs. males, AHR=1.07, 95%CI:1.01-1.13), the group aged ≥50 years (vs. the group aged 18-49 years, AHR=0.50-0.87, 95%CI:0.46-0.91), cohabitants (vs. the married,AHR=0.89, 95%CI:0.81-0.97), Zhuang ethnic group (vs. Han ethnic group,AHR=1.06, 95%CI:1.02-1.11), junior high school education level or above (vs. primary school or below, AHR=1.13-1.24, 95%CI:1.08-1.33), the group with recent CD4 count ≥ 200 cells/μl (vs. the group with recent CD4 count < 200 cells/μl , AHR=0.45-0.95, 95%CI:0.42-1.00), the group without CD4 cell testing (vs. the group with CD4 count < 200 cells/μl, AHR=0.28, 95%CI:0.24-0.33), and samples from medical institutions (vs. HIV voluntary counseling and testing (VCT), AHR=0.91, 95%CI:0.87-0.96), from premarital check-up/pregnancy testing/ prenatal examination (vs. VCT, AHR=0.78, 95%CI:0.72-0.84) and from other sources (vs. VCT, AHR=0.72, 95%CI:0.65-0.79). Conclusions Corresponding strategies should be made based on the related factorsinfluencing ARTso as to further improve the ART rate in sero-positive partners and control HIV-1 transmission in HIV-1 sero-discordant couples. We should make effortsto mobilize patients to receive ART,pay special attention to the elderly, people with low educational background and those with high CD4 cell count, and guide patients to receive ART as early as possible.
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2020, Vol. 27 
