Surveillance of adverse reactions following immunization with live attenuated Japanese encephalitis vaccine in Chenzhou city, Hunan province, 2011-2018
HUANG Kai1,2, DUAN Liang-song1, LIU Xiao-feng1, LI Ying-xia1, LIU Ge-qun1, LI Cheng-hua1
1. Chenzhou Municipal Center for Disease Control and Prevention, Chenzhou, Hunan 423000, China; 2. Luohu District Center for Disease Control and Prevention, Shenzhen, Guangdong 518000, China
Abstract：Objective To analyze the characteristics of adverse reactions for live attenuated Japanese encephalitis vaccine (JEV-L) and the safety profile of JEV-L in Chenzhou city from 2011 to 2018. Methods The data regarding adverse events following immunization of JEV-L in Chenzhou during 2011-2018 were collected from the National Adverse Events Following Immunization Surveillance System, and then descriptive epidemiological method was used for analysis. Results A total of 421 cases of adverse reactions caused by JEV-L were reported in Chenzhou city during 2011-2018, with an average annual reported incidence rate of 43.55 per 100,000 doses administered. Among the cases reported, 404 cases (95.96 %, 41.79/100,000 doses) were common reactions, and 17 (4.04 %, 1.76/100,000 doses) were abnormal reactions. The male to female ratio was 1.38∶1, and children aged < 3 years accounted for 92.16 %. Most of thereported casesoccurred in the second quarter,accounting for 42.99%. The incidence rate of adverse reactions of the first dose was significantly higher than that of the second dose, with a statistically significant difference (χ2=37.22, P<0.01). 98.81 % of adverse reactions occurred within 24 hours after the vaccination. Conclusions JEV-L has a good safety profile; however, surveillance of adverse reactions for JEV-L still should be strengthened.
黄凯, 段良松, 刘晓峰, 李映霞, 刘鸽群, 李成华. 2011—2018年郴州市乙型脑炎减毒活疫苗预防接种不良反应监测分析[J]. 实用预防医学, 2020, 27(9): 1086-1088.
HUANG Kai, DUAN Liang-song, LIU Xiao-feng, LI Ying-xia, LIU Ge-qun, LI Cheng-hua. Surveillance of adverse reactions following immunization with live attenuated Japanese encephalitis vaccine in Chenzhou city, Hunan province, 2011-2018. , 2020, 27(9): 1086-1088.
2020, Vol. 27 
