Clinical characteristics of 8 death cases with coronavirus disease 2019
SHI Qing-hong1, GONG Zi-long1, WU Yue1, LI Qian1, MA Dan1, CAI Hang-hang2
1. The Fifth Hospital of Wuhan City, Wuhan, Hubei 430050, China; 2. Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430000, China
Abstract:Objective To explore the death causes and possible risk factors of 8 death cases with coronavirus disease 2019 (COVID-19). Methods We retrospectively analyzed the clinical characteristics of 8 COVID-19 cases which died duringhospitalization from January 23 to February 25 in 2020. Results The 8 death cases with COVID-19 were between the ages of 65 and 75, the mean age was (70.63±3.99) years and the average course of disease was (12±2.83) days. All the 8 death cases had underlying diseases, and the most common disease was hypertension, followed by cerebral infarction, diabetes, coronary heart disease and underlying diseases related to lung. Besides lung damage, heart, kidney and liver damages and coagulation dysfunction were also observed, and the level of D-dimer increased significantly in 4 (4/8) death cases. Leukocyte and neutrophil counts and the levels of C-reactive protein (CRP) and procalcitonin (PCT) were elevated in 6(6/8), 6(6/8), 8(8/8) and 8(8/8) cases, respectively. Lymphocyte count declined in 4 (4/8) cases, and lymphocyte percentage in 8 (8/8) cases. The levels of leukocyte (8/8), neutrophil (8/8), PCT (8/8) and D-dimer (8/8) in the last test before death were increased as compared with those in the first test during hospitalization, whereas the level of PaO2 (8/8), lymphocyte count (7/8) and lymphocyte percentage (8/8) were decreased as compared with those in the first test during hospitalization, showing statistically significant differences (all P<0.05). Chest CT showed an increased number and range of lung lesions as compared with admitting hospital. Conclusions Advanced age and underlying diseases are the important risk factors for the difficulty of COVID-19 rescue and even death, and bacterial infection may play an important role in promoting the progression of the disease. Pa02, chest CT, the counts of leukocyte, neutrophil and lymphocyte, lymphocyte percentage, CRP, PCT and D-dimer may be used as important reference indicators for disease progression and poor prognosis.
石清红, 龚子龙, 吴越, 李倩, 马丹, 蔡航航. 8例新型冠状病毒肺炎死亡病例临床特征分析[J]. 实用预防医学, 2020, 27(9): 1032-1036.
SHI Qing-hong, GONG Zi-long, WU Yue, LI Qian, MA Dan, CAI Hang-hang. Clinical characteristics of 8 death cases with coronavirus disease 2019. , 2020, 27(9): 1032-1036.
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