Abstract:Objective To evaluate the relationship between human leukocyte antigen DQB1 (HLA-DQB1) allele and tuberculosis incidence based on a meta-analysis. Methods PubMed, Embase, Cochrane library, Ciki, WanFang and VIP databases were searched for literatures related to alleles of HLA-DQB1 and risk of onset of tuberculosis, and then data extraction and quality evaluation were conducted. REVMAN5.0 and Stata13.1 software packages were used for the meta-analysis of relationship between alleles of HLA-DQB1 and risk of onset of tuberculosis. Results A total of 18 related literatures were included in this study, involving 1,674 tuberculosis patients in the case group and 1,906 controls in the control group. The results of the meta-analysis revealed that HLA-DQB1 *0601, HLA-DQB1*0609 were correlated with the risk of onset of tuberculosis. Conclusion Specific HLA-DQB1 allele may be a susceptibility marker to predict the risk of onset of tuberculosis.
[1] 陈其琛, 刘国标, 李笑颜, 等. 广州市越秀区2013—2017年本地居民肺结核流行特征 [J]. 实用预防医学, 2019,26(9):1121-1125. [2] Kurmi OP, Sadhrac S, Ayres JG, et al. Tuberculosis risk from exposure to solid fuel smoke: a systematic review and meta-analysis [J]. JEpidemiol Commun H, 2014, 68(12):1112-1118. [3] 刘婷, 向延根, 范任华, 等. 肺结核病人细胞因子的研究进展 [J]. 实用预防医学, 2016, 23(7):894-897. [4] Ma MJ, Xie LP, Wu SC, et al. Toll-like receptors, tumor necrosis factor-alpha, and interleukin-10 gene polymorphisms in risk of pulmonary tuberculosis and disease severity [J]. Human Immunol, 2010, 71(10):1005-1010. [5] Akgunes A, Coban AY, Durupinar B. Human leucocyte antigens and cytokine gene polymorphisms and tuberculosis [J]. Indian J Med Microbiol, 2011, 29(1):28-32. [6] Spinola H, Middleton D, Brehm A. HLA genes in Portugal inferred from sequence-based typing: in the crossroad between Europe and Africa[J]. Tissue Antigens, 2005, 66(1):26-36. [7] 赵雁林, 端木宏谨, 宋长兴. 人类白细胞抗原-DRB1和DQB1基因与肺结核合并糖尿病的相关性分析 [J]. 中华结核和呼吸杂志, 2001,47(2):10-14. [8] 宿罡. Eales病与人类白细胞抗原基因多态性和结核感染的相关研究 [D].遵义: 遵义医学院, 2009. [9] 吴江东. 新疆汉族与哈萨克族HLA-DRB1、DQB1、DPB1等位基因频率与结核病相关性研究及新基因的发现 [D].武汉:华中科技大学, 2016. [10] 王喜, 任玲君, 李秀玲, 等. 新疆维吾尔族人群HLA-DR、DQ基因多态性与结核病易感性的研究 [J]. 中国防痨杂志, 2011,33 (4):197-203. [11] Wu F, Zhang W, Zhang L, et al. NRAMP1, VDR, HLA-DRB1, and HLA-DQB1 gene polymorphisms in susceptibility to tuberculosis among the Chinese Kazakh population: a case-control study [J]. Biomed Res Int, 2013,2013:484535. [12] Wamala D, Buteme HK, Kirimunda S, et al. Association between human leukocyte antigen class II and pulmonary tuberculosis due to mycobacterium tuberculosis in Uganda [J]. BMC Infect Dis, 2016, 16:23. [13] Vejbaesya S, Chierakul N, Luangtrakool K, et al. Associations of HLA class II alleles with pulmonary tuberculosis in Thais [J]. EurJ Immunogenet, 2002, 29(5):431-434. [14] Teran-Escandon D, Teran-Ortiz L, Camarena-Olvera A, et al. Human leukocyte antigen-associated susceptibility to pulmonary tuberculosis:molecular analysis of class II alleles by DNA amplification and oligonucleotide hybridization in Mexican patients [J]. Chest, 1999, 115(2):428-433. [15] Sanjeevi CB, Narayanan PR, Prabakar R, et al. No association or linkage with HLA-DR or -DQ genes in south Indians with pulmonary tuberculosis [J]. Tuber Lung Dis, 1992, 73(5):280-284. [16] Ravikumar M, Dheenadhayalan V, Rajaram K, et al. Associations of HLA-DRB1, DQB1 and DPB1 alleles with pulmonary tuberculosis in south India [J]. Tuber Lung Dis, 1999, 79(5):309-317. [17] Mehra NK, Verduijn W, Taneja V, et al. Analysis of HLA-DR2-associated polymorphisms by oligonucleotide hybridization in an Asian Indian population [J]. Hum Immunol, 1991, 32(4):246-253. [18] Lombard Z, Dalton DL, Venter PA, et al. Association of HLA-DR, -DQ, and vitamin D receptor alleles and haplotypes with tuberculosis in the Venda of South Africa[J]. Hum Immunol, 2006, 67(8):643-654. [19] Leblanc SB, Naik EG, Jacobson L, et al. Association of DRB1*1501 with disseminated Mycobacterium avium complex infection in NorthAmerican AIDS patients [J]. Tissue Antigens, 2000, 55(1):17-23. [20] Kuranov AB, Kozhamkulov UA, Vavilov MN, et al. HLA-class II alleles in patients with drug-resistant pulmonary tuberculosis in Kazakhstan [J]. Tissue Antigens, 2014, 83(2):106-112. [21] Kim HS, Park MH, Song EY, et al. Association of HLA-DR and HLA-DQ genes with susceptibility to pulmonary tuberculosis in Koreans: preliminary evidence of associations with drug resistance, disease severity, and disease recurrence [J]. Hum Immunol, 2005, 66(10):1074-1081. [22] Goldfeld AE, Delgado JC, Thim S, et al. Association of an HLA-DQ allele with clinical tuberculosis [J]. JAMA, 1998, 279(3):226-228. [23] Dubaniewicz A, Moszkowska G, Szczerkowska Z. Frequency of DRB1-DQB1 two-locus haplotypes in tuberculosis:preliminary report [J]. Tuberculosis (Edinb), 2005, 85(4):259-267. [24] Amirzargar AA, Yalda A, Hajabolbaghi M, et al. The association of HLA-DRB, DQA1, DQB1 alleles and haplotype frequency in Iranian patients with pulmonary tuberculosis[J]. Int J Tuberc Lung Dis, 2004, 8(8):1017-1021. [25] Cai SJ, Su G, Li H, et al. Profiling of human leukocyte antigens in Eales disease and tuberculosis [J]. Int Ophthalmol, 2013, 33(5):475-479. [26] 任福贵. 结核病发病机制及诊断的研究进展 [J]. 社区医学杂志, 2016, 14(24):58-60. [27] Li CP, Zhuo Y, Xiang X, et al. Relationship of HLA-DRB1 gene polymorphism with susceptibility to pulmonary tuberculosis:updated meta-analysis[J]. Int J Tuberc Lung Dis, 2015, 19(7):841-849. [28] Yi Z, Li J, Gao K, et al. Identifcation of differentially expressed long non-coding RNAs in CD4+ T cells response to latent tuberculosis infection[J]. J Infect, 2014, 69(6):558-568.