Abstract:Objective To systematically evaluate the effect of nutritional support on the prognosis of nasopharyngeal carcinoma (NPC) patients with radiotherapy so as to provide a basis for prevention of complications and side effects after radiotherapy for NPC. Methods We systematically searched literatures referring to the effects of nutritional intervention on NPC patients with radiotherapy issued from January, 2004 to June, 2019 in the databases of China National Knowledge Infrastructure (CNKI), WanFang, VIP, Web of Science, PubMed, the Cochrane Library and EMbase. Meta-analysis was performed using Stata 12.0 software, Q-test and I2 statistic were used to evaluate the heterogeneity between the results of the study using the Stata 12.0 software, and the funnel plot was used to evaluate publication bias. Results Thirteen randomized controlled trials were includedin this analysis, involving a total of1,296 cases. Meta-analysis showed that body mass index (OR=0.325, 95%CI:0.107-0.991), hemoglobin (SMD=0.926, 95%CI:0.56-1.293), albumin (SMD=0.726, 95%CI:0.479- 0.973) and radioactive skin reaction (grades Ⅲ-Ⅳ) (OR=0.242, 95%CI:0.171-0.343) in the nutritional support group of NPC patients with radiotherapy were superior to those in the control group (the non-nutritional support group). No statistically significant difference was found in the incidence rate of oropharyngeal mucosal injury (grades III-IV) (OR=0.929, 95%CI:0.576-1.479). Conclusions Nutritional support plays a positive role in maintaining the nutritional parameters of NPC patients during radiotherapy; moreover, it reduces the risk ofacuteradiation skin reaction (grades Ⅲ-Ⅳ). However, its impact on the reduction of oral mucosal injury is not yet clear and needs more studies.
张云霄, 付由户, 何明艳, 王雷, 钟媛, 杨柳, 让蔚清. 营养支持对鼻咽癌放疗患者影响的meta分析[J]. 实用预防医学, 2020, 27(4): 406-409.
ZHANG Yun-xiao, FU You-hu, HE Ming-yan, WANG Lei, ZHONG Yuan, YANG Liu, RANG Wei-qing. Effect of nutritional support on nasopharyngeal carcinoma patients with radiotherapy: a meta-analysis. , 2020, 27(4): 406-409.
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