Abstract：Objective To determine the changes of serum contents of five phosphatides in patients with type 2 diabetes mellitus using high performance liquid chromatography (HPLC). Methods Serum samples were collected from 70 patients with type 2 diabetes mellitus and 81 normal controls for determination of phosphatidylserine (PS), phosphatidylinostiol (PI), phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) by HPLC, and for comparison between the two groups. Results The serum contents of PS ((0.139±0.031) mg/L vs. (0.154±0.029) mg/L)), PI ((0.021±0.016) mg/L vs. (0.027±0.017) mg/L), PC ((0.150±0.039) mg/L vs. (0.385±0.022) mg/L) and PE ((0.070±0.026) mg/L vs. (0.087±0.044) mg/L) were lower in the patients with type 2 diabetes mellitus than in the normal controls, with statistically significant differences (all P<0.05). No statistically significant difference was discovered in the serum content of SM ((0.039±0.026) mg/L vs. (0.044±0.028) mg/L) between the two groups (P>0.05). Conclusions Serum PS, PI, PC and PE decline in the patients with type 2 diabetes mellitus , and they may play adjuvant roles in the screening of diabetes mellitus among normal population.
吴越, 朱敬丽, 姚建, 路赵硕, 王德才. HPLC法测定2型糖尿病患者血清中磷脂含量的变化[J]. 实用预防医学, 2017, 24(5): 533-535.
WU Yue, ZHU Jing-li, YAO Jian, LU Zhao-shuo, WANG De-cai. Changes of serum phosphatide contents in patients with type 2 diabetes mellitus determined by high performance liquid chromatography. , 2017, 24(5): 533-535.
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2017, Vol. 24 
