Incidence and mortality of nasopharyngeal carcinoma in China's tumor registration areas, 2005-2013
WANG Lei1, ZHANG Yun-xiao1, YANG Liu1, SHEN Wan-ying1, LIAO Xian-zhen2, RANG Wei-qing1
1. School of Public Health, University of South China, Hengyang, Hunan 421001, China; 2. Hunan Provincial Tumor Hospital, Changsha, Hunan 410013, China
Abstract：Objective To analyze the incidence and mortality of nasopharyngeal carcinoma in China according to the registered information of nasopharyngeal carcinoma in China Cancer Registry Annual Reports in 2005-2013, and to provide a scientific basis for formulating nasopharyngeal carcinoma prevention and control strategies in China. Methods We collected the data about the incidence and mortality of nasopharyngeal carcinoma in China from 2005 to 2013. The Joinpoint regression model was used to analyze the temporal changing trends of standardized morbidity and mortality of nasopharyngeal carcinoma and the trends of the age-specific incidence. Results The incidence rates of nasopharyngeal carcinoma showed an overall downward trend. There was a significant turning point in the incidence in 2009-2010. The incidence rate of nasopharyngeal carcinoma in cities showed an upward trend before 2009 (APC=2.97%, P=0.30) but a downward trend after 2009 (APC=-5.75%, P<0.05). The incidence rate of nasopharyngeal carcinoma in rural areas showed a rapid decreasing trend before 2009 (APC=-17.64%, P=0.20) but a slow upward trend after 2009 (APC=4.24%, P=0.60). The gap between urban and rural areas was gradually narrowing. The standardized incidence rates of nasopharyngeal carcinoma in Chinese males in 2005-2013 were all higher than those in Chinese females, which were 2.30-2.45 times those of Chinese females. The incidence rates of males and females presented an overall decreasing trend with time (APC<0, P<0.05). The age-specific incidence rate of nasopharyngeal carcinoma in population aged 0-25 years was milder and lower, and the incidence rate in population aged 25-60 years gradually increased with age, and the peak incidence in each year during 2005-2013 was found in the age group of 50-60 years. The mortality rates of nasopharyngeal carcinoma in 2009- 2010 displayed a significant turning point, of which the mortality rate in cities showed an upward trend before 2009 (APC=3.09%, P=0.20) but a downward trend after 2009 (APC=-7.27%, P<0.05). The mortality rate of nasopharyngeal carcinoma in rural areas showed a rapid decreasing trend before 2009 (APC=-22.81%, P=0.10) but a slow upward trend after 2009 (APC=3.60%, P=0.60). The gap between urban and rural areas was gradually narrowing. The standardized mortality rates of nasopharyngeal carcinoma in Chinese males in 2005-2013 were all higher than those in Chinese females, which were 2.54-3.09 times those of Chinese females. The mortality rates of male and female patients displayed an overall decreasing trend with time (APC<0, P<0.05). The trends of age-specific mortality rates of nasopharyngeal carcinoma in population aged 0-25 years were relatively flat and low in generally, but the age-specific mortality rate in population above 25 years old in each year displayed an upward trend with age. Conclusions The incidence rates and mortality rates of nasopharyngeal carcinoma in China in 2005-2013 showed a downward trend in general. There were obvious age and gender differences in the morbidity and mortality. The urban-rural gap gradually narrowed. The incidence and mortality rates in population above 25 years old showed an upward trend and maintained a high level. Special attention should be paid to prevention and treatment situation of nasopharyngeal cancer in males over 25 years of age.
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2020, Vol. 27 
