[1] Siegel R, Desantis C, Jemal A. Colorectal cancer statistics[J].CA Cancer J Clin, 2014, 64(2):104-117. [2] 袁平,郑奎城.胃癌流行病学研究进展[J].慢性病学杂志,2018,19(12):1671-1675. [3]秦叔逵, 龚新雷. 晚期胃癌化疗的现状和新进展[J]. 临床肿瘤学杂志, 2006, 11(9):641-652. [4] Tang HB, Li YS, Arihiro K, et al. Activation of the neurokinin-1 receptor by substance P triggers the release of substance P from cultured adult rat dorsal root ganglion neurons[J]. Mol Pain, 2007, 3(1):42. [5] Huang WQ, Wang JG, Lei C, et al. SR140333 counteracts NK-1 mediated cell proliferation in human breast cancer cell line T47D[J]. J Expclin Canc Res,2010, 29(1):55. [6] Rosso M, Roblesfrías MJ, Coveñas R, et al. The NK-1 receptor is expressed in human primary gastric and colon adenocarcinomas and isinvolved in the antitumor action of L-733,060 and the mitogenic action of substance P on human gastrointestinal cancer cell lines[J]. Tumor Biol, 2008, 29(4):245-254. [7] 张洪伟, 王为忠, 宋俊峰,等. P物质对胃癌细胞增殖的作用[J]. 中华实验外科杂志, 2007, 24(6):694-696. [8] Garciarecio S, Gascón P. Biological and pharmacological aspects of the NK1-receptor[J]. Biomed Res Int, 2015, 2015(1):495704. [9] Muñoz M, Gonzálezortega A, Rosso M, et al. The substance P/neurokinin-1 receptor system in lung cancer:focus on the antitumor action of neurokinin-1 receptor antagonists[J]. Peptides, 2012, 38(2):318-325. [10] González-Ortega A, Sánchez-Vaderrábanos E, Ramiro-Fuentes S, et al. Uveal melanoma expresses NK-1 receptors and cyclosporin A induces apoptosis in human melanoma cell lines overexpressing the NK-1 receptor[J]. Peptides, 2014, 55(5):1-12. [11] Muñoz M, Rosso M, González-Ortega A, et al. The NK-1 receptor antagonist L-732,138 induces apoptosis and counteract substance P-related mitogenesis in human melanoma cell lines[J]. Cancers, 2010,2(2):611-623. [12] Muñoz M, Rosso M, Coveñas R. A new frontier in the treatment of cancer: NK-1 receptor antagonists[J]. Curr Med Chem, 2010, 17(6):504-516. [13] 卢燕. 神经激肽受体的两种拮抗剂对结肠癌细胞增殖的作用及其机制研究[D]. 杭州:浙江理工大学, 2015. [14] Miguel M, Rafael C. Neurokinin-1 receptor antagonists as antitumor drugs in gastrointestinal cancer: a new approach[J]. Saudi J Gastroenterol, 2016, 22(4):26-268. [15] Li J, Zeng Q, Zhang Y, et al. Neurokinin-1 receptor mediated breast cancer cell migration by increased expression of MMP-2 and MMP-14[J]. Eur J Cell Biol, 2016, 95(10):368-377. [16] Rojas C, Raje M, Tsukamoto T, et al. Molecular mechanisms of 5-HT 3, and NK 1, receptor antagonists in prevention of emesis[J]. Eur J Pharmacol, 2014, 722(1):26-37. [17] Ptak K, Burnet H, Blanchi B, et al. The murine neurokinin NK1 receptor gene contributes to the adult hypoxic facilitation of ventilation[J]. Eur J Neurosci, 2015, 16(12):2245-2252. [18] Huang SC, Korlipara VL. Neurokinin-1 receptor antagonists:a comprehensive patent survey[J]. Expert Opin Ther Pat, 2010, 20(8):1019-1045.
2019, Vol. 26 
