Research progress on the establishment of animal models of chronic obstructive pulmonary disease
MA Hui-min1,2, LIU Qi-zhan2, LU Lu1, SHI Ai-min1,2
1. Animal Care Facility of Nanjing Medical University, Jiangsu, Nanjing 211166, China; 2. Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China
Abstract：Chronic obstructive pulmonary disease (COPD) is a common respiratory disease with high morbidity and mortality. In severe cases, it can develop a progressive decline in lung function, respiratory failure, pulmonary heart disease, etc. However, the current pathogenesis is still unclear. Animal models are effective tools for conducting COPD research. Establishing a reasonable animal model is of great significance for further exploring the pathogenesis of COPD and developing new methods and new drugs for treating COPD. Therefore,how to create an animal model that is simple, reproducible, and capable of replicating human clinical features is critical to the research subjects. This is a systematic review of modeling overview of current animal models for COPD.
马慧敏, 刘起展, 陆璐, 施爱民. 慢性阻塞性肺病动物模型建立的研究进展[J]. 实用预防医学, 2019, 26(11): 1406-1502.
MA Hui-min, LIU Qi-zhan, LU Lu, SHI Ai-min. Research progress on the establishment of animal models of chronic obstructive pulmonary disease. , 2019, 26(11): 1406-1502.
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2019, Vol. 26 
