[1] Quail DF, Joyce JA. Microenvironmental regulation of tumor progression and metastasis[J]. Nat Med, 2013,19(11):1423-1437. [2] McAllister SS, Weinberg RA. The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis[J]. Nat Cell Biol, 2014, 16(8):717-727. [3] Noh H, Eomm M, Han A. Usefulness of pretreatment neutrophil to lymphocyte ratio in predicting disease-specific survival in breast cancer patients[J]. J Breast Cancer, 2013, 16(1):55-59. [4] Azab B. Usefulness of the neutrophil-to-lymphocyte ratio in predicting short-and long-term mortality in breast cancer patients[J]. Ann Surg Oncol, 2012, 19(1):217-224. [5] Granot Z, Henke E, Comen EA, et al. Tumor entrained neutrophils inhibit seeding in the premetastatic lung[J]. Cancer Cell, 2011, 20(3):300-314. [6] Kowanetz M, Quast T, Landsberg J,et al . Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G1Ly6C1 granulocytes[J]. Proc Natl Acad Sci U S A, 2017, 107(50):21248-21255. [7] Bald T, Wu X, Lee J,et al. Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma[J]. Nature, 2014, 507(7490):109-113. [8] Schoenborn JR, Wilson CB. Regulation of interferon-gamma during innate and adaptive immune responses[J]. Adv Immunol, 2007,96:41-101. [9] Chavez-Galan L, Arenas-Del Angel MC, Zenteno E, et al. Cell death mechanisms induced by cytotoxic lymphocytes[J]. Cell Mol Immunol, 2009, 6(1):15-25. [10] Kuwano K, Kawashima T, Arai S. Antiviral effect of TNF-alpha and IFN-gamma secreted from a CD8+ influenza virus-specific CTL clone[J]. Viral Immunol, 1993, 6(1):1-11. [11] Slifka MK, Whitton JL. Antigen-specific regulation of T cell-mediated cytokine production[J]. Immunity,2000, 12(5):451-457. [12] 廖楚舒, 邓中华, 乐杨桦, 等. Th17相关炎症因子与原发性肝癌关系的研究[J].实用预防医学, 2016, 23 (5):554-556. [13] Derksen PW, Liu X, Saridin F, et al. Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis[J]. Cancer Cell,2006,10(5):437-449. [14] Doornebal CW, Klarenbeek S, Braumuller TM, et al. A preclinical mouse model of invasive lobular breast cancer metastasis[J]. Cancer Res,2013,739(1):353-363. [15] Chung Y, Chang SH, Martinez GJ, et al. Critical regulation of early Th17 cell differentiation by interleukin-1 signaling[J]. Immunity,2009,30(4):576-587. [16] Cai Y, Shen X, Ding C. Pivotal role of dermal IL-17-producing cd T cells in skin inflammation[J]. Immunity, 2011, 35(4):596-610. [17] Mei J, Liu Y, Dai H, et al. Cxcr2 and Cxcl5 regulate the IL-17/G-CSF axis and neutrophil homeostasis in mice[J]. J Clin Invest, 2012, 122(3):974-986. [18] Sutton CE, Lalor SJ, Sweeney CM, et al. Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity[J]. Immunity, 2009, 31(2):331-341. [19] Kaplan RN, Riba RD, Zacharoulis S, et al. VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche[J]. Nature, 2005, 438(7069):820-827. [20] Hiratsuka S, Watanabe A, Aburatani H,et al. Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis[J]. Nat Cell Biol, 2006, 8(12):1369-1375. [21] Han Y, Yu Z, Wen S, et al. Prognostic value of chemotherapy-induced neutropenia in earlystage breast cancer[J]. Breast Cancer Res Treat, 2012, 131(2):483-490. [22] Ma C, Zhang Q, Ye J,et al. Tumor-infiltrating Yō T lymphocytes predict clinical outcome in human breast cancer[J]. J Immunol, 2012, 189(10):5029-5036. [23] Novitskiy SV, Pickup MW, Gorska AE, et al. TGF-β receptor II loss promotes mammary carcinoma progression by Th17 dependent mechanisms[J]. Cancer Discov, 2011, 1(5):430-441. [24] Chen WC, Lai YH, Chen HY, et al. Interleukin-17-producing cell infiltration in the breast cancer tumour microenvironment is a poor prognostic factor[J]. Histopathology, 2013, 63(2):225-233.