Abstract:Objective To study the association between depression and serum 25-hydroxy vitamin D (25-OH-VD) level in puerperae with the second pregnancy and its influence on delivery mode. Methods One hundred puerperae who suffered from depression during the second pregnancy and delivered in Wuhan Youfu Hospital from February 2016 to February 2018 were enrolled in the study group, whereas 100 puerperae who did not suffer from depression during the second pregnancy and simultaneously delivered in the same hospital were selected as the control group. The scores of Self-rating Anxiety Scale (SAS) and Hamilton Depression Rating Scale (HAMD) and serum 25-OH-VD level were compared between the two groups, and the correlation of depression with SAS score and serum 25-OH-VD level was analyzed. In addition, the mode of delivery was compared between the two groups, and multivariate logistic regression analysis was performed. Results The scores of SAS and HAMD in puerperae of the study group were significantly higher than those of the control group (both P<0.05), while the serum 25-OH-VD level was significantly lower in the study group than in the control group (P<0.05). Pearson correlation analysis showed that the score of HAMD in puerperae with the second pregnancy was positively correlated with the score of SAS (P<0.05), but negatively correlated with serum 25-OH-VD level (P<0.05). The proportion of spontaneous delivery was significantly lower in the study group than in the control group, while the proportion of cesarean section was significantly higher in the study group than in the control group (P<0.05). Multivariate logistic regression analysis showed that high SAS score, high HAMD score and low serum 25-OH-VD level were independent risk factors for poor delivery mode in puerperae with the second pregnancy (all P<0.05). Conclusions There is a significant negative correlation between depression and serum 25-OH-VD level in puerperae with the second pregnancy; moreover, depression and the decrease of serum 25-OH-VD level may increase the risk of poor delivery mode in them.
朱倩芸, 汤珺, 杨灿, 刘婷, 冯晓薇. 二次妊娠产妇抑郁情绪与血清25-羟基维生素D水平的关系以及对分娩方式的影响[J]. 实用预防医学, 2019, 26(10): 1197-1200.
ZHU Qian-yun, TANG Jun, YANG Can, LIU Ting, FENG Xiao-wei. Relationship between depression and serum 25-hydroxy vitamin D levelin puerperae with the second pregnancy and its impact on mode of delivery. , 2019, 26(10): 1197-1200.