Abstract：Objective To study the levels and distribution characteristics of serum perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in the general population in Wuhan city, and to provide a scientific basis for formulating laws and regulations that govern PFOS and PFOA pollution. Methods A stratified random sampling method was used to collect serum samples from adults, who had lived in Wuhan city for over five years and had no occupational exposure history, and children in 2014-2015. The concentration of serum PFOS and PFOA were determined by high performance liquid chromatography and tandem mass spectrometry (HPLC/MS/MS). Statistical analysis was performed using SPSS 22.0 software package. Results The detection rates of serum PFOS in the general population in Wuhan city were 75.4% (the children group) and 83.3% (the adult group), respectively, and those of serum PFOA were 80.5% (the children group) and 82.9% (the adult group), respectively. No statistically significant differences were found in the concentration of serum PFOS and PFOA between the urban and rural children groups as well as between the male and female adult groups (both P>0.05). In the urban area, the concentration of serum PFOS of the female adult group (M=2.40 ng/ml, P25=1.58 ng/ml, P75=3.95 ng/ml) was higher than that of the female children group ((M=2.00 ng/ml, P25=0.23 ng/ml, P75=3.20 ng/ml), (Z=-2.565,P=0.010)), but the concentration of serum PFOA of the maleadult group (M=1.80 ng/ml, P25=0.25 ng/ml, P75=5.82 ng/ml) was lower than that of the male children group ((M=3.60 ng/ml, P25=1.13 ng/ml, P75=10.00 ng/ml), (Z=-2.158,P=0.031)). In the rural area, the concentration of serum PFOA of the male adult group (M=1.29 ng/ml, P25=0.05 ng/ml, P75=3.60 ng/ml) was lower than that of the male children group ((M=4.07 ng/ml, P25=0.24 ng/ml, P75=8.34 ng/ml), (Z=-2.820,P=0.005)). The concentration of serum PFOS (M=2.40 ng/ml, P25=1.58 ng/ml, P75=3.95 ng/ml) and PFOA (M=3.30 ng/ml, P25=0.85 ng/ml, P75=6.85 ng/ml) in the urban female adult group was higher than that in the rural female adult group ((M=0.48 ng/ml, P25=0.05 ng/ml, P75=5.02 ng/ml), (Z=-4.316, P<0.001); (M=0.88 ng/ml, P25=0.24 ng/ml, P75=4.05 ng/ml), (Z=-3.639,P<0.001)). There was a positive correlation between serum PFOS and PFOA concentration in the population in Wuhan city. Conclusions Some factors like district, age and physiologic status may lead to differences in the levels of serum PFOS and PFOA of the population. Dietary intake may be the common route exposed to PFOS and PFOA in the population in Wuhan.
刘俊玲, 肖永华, 潘新赟, 何振宇. 武汉市一般人群血清中全氟辛烷磺酸和全氟辛酸分布特征[J]. 实用预防医学, 2019, 26(9): 1075-1079.
LIU Jun-ling, XIAO Yong-hua, PAN Xin-yun, HE Zheng-yu. Distribution characteristics of serum perfluorooctane sulfonate and perfluorooctanoate in the general population in Wuhan city. , 2019, 26(9): 1075-1079.
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2019, Vol. 26 
