Epidemiological characteristics of human rabies and factors affecting its incubation period in Nanning City, 2005-2017
TANG Jin-fang1, LU Wan-zhu2, LIANG Ling-zhi1, GAN Wen-ye1, CHEN Hai-bin1
1. Nanning Center for Disease Control and Prevention,Nanning,Guangxi 530028, China 2. Xingning District Center for Disease Control and Prevention,Nanning,Guangxi 530028, China
Abstract：Objective To analyze the epidemiological characteristics of human rabies in Nanning City during 2005-2017, to explore the factors influencing its incubation period, and to provide a scientific basis for prevention and control of human rabies. Methods The data regarding human rabies cases in Nanning City during 2005-2017 were collected, and descriptive epidemiological method was used to analyze time, region and population distribution characteristics of human rabies. SPSS20.0 software was employed to perform univariate analysis, multivariate linear stepwise regression analysis and ordinal regression analysis. Results The incidence rate of human rabies in Nanning City during 2005-2017 showed a downward tendency (χ2trend=203.95, P<0.001). The cases were reported in all counties and districts. The incidence was higher in counties than in urban areas (0.36/100,000 vs. 0.14/100,000, χ2=37.37,P<0.001) as well as higher in males than in females (0.36/100,000 vs. 0.18/100,000, χ2=26.20, P<0.001). Cases aged > 40 years accounted for 69.57%, and most of the patients were farmers(81.03%). The rate of vaccination with human rabies vaccine was 11.46% after the patients had been bitten or scratched by animals. The median of human rabies incubation period was 71 days (ranging from 3 to 2,459 days). The incubation period was related to exposure degree, exposure region, wound disposal, antiserum/immunoglobulin injection for post-exposure, human rabies vaccine injection for post-exposure, animal species and animal origin (P<0.05), and the head and face exposure had the greatest impact on the incubation period, with the median incubation period being 18 days (OR=0.12, OR95%CI:0.042-0.345). Conclusions As for strengthening the propaganda regarding rabies prevention and control knowledge, special attention should be paid to farmers, men and people over the age of 40. The incubation period of human rabies is influenced by many factors, but increasing the wound disposal rate and improving the rate of vaccination against rabies are the main measures to prevent and control human rabies.
唐金芳, 陆婉珠, 梁灵芝, 甘文烨, 陈海滨. 2005－2017年南宁市狂犬病流行病学特征及潜伏期影响因素分析[J]. 实用预防医学, 2019, 26(6): 667-671.
TANG Jin-fang, LU Wan-zhu, LIANG Ling-zhi, GAN Wen-ye, CHEN Hai-bin. Epidemiological characteristics of human rabies and factors affecting its incubation period in Nanning City, 2005-2017. , 2019, 26(6): 667-671.
2019, Vol. 26 
