Characteristics of HCV genotypes of outpatients in methadone maintenance treatment clinics in Hunan Province
DAI Jun-bin1, WANG Fang-yu1,2, ZOU Xiao-bai3, CHEN Xi3, HE Jian-mei3
1. Hengyang Medical College, University of South China, Hengyang, Hunan 421001, China; 2. College of Life Science and Environment, Hengyang Normal University, Hengyang, Hunan 421008, China; 3. Hunan Provincial Center for Disease Control and Prevention, Changsha, Hunan 410005, China
Abstract：Objective To investigate the characteristics of HCV genotypes of outpatients in methadone maintenance treatment clinics in Hunan Province. Methods A total of 210 plasma samples were collected from outpatients aged above 18 years, without antiviral therapy and with positive anti-HCV antibody in methadone maintenance treatment clinics in 14 cities/prefectures in Hunan Province, and 15 plasma samples were collected from each city/prefecture. All the samples were tested with HCV antibody ELISA, HCV-RNA fluorescent quantitative polymerase chain reaction (FQ-PCR) method and genotyping assay. Results Among all the surveyed subjects, 202 (96.19%) were positive for anti-HCV antibody reconfirmed by ELISA method, and 181 (86.19%) were positive for HCV-RNA by FQ-PCR method, with the viral load of >15 IU/ml. There were 18 (9.94%) cases of HCV genotype 1 infection, 51 (28.18%) cases of HCV genotype 2/3 infection, 47 (25.97%) cases of HCV mixed genotype 1 and 2/3 infection, and 65 (35.91%) cases of other genotype infections. Regional distribution showed that the genotype non-1 was the main HCV genotype, and the genotype 2/3 was the common genotype. Conclusions HCV genotypes in Hunan Province are complex, and it needs to be further studied.
戴俊斌, 王芳宇, 邹潇白, 陈曦, 贺健梅. 湖南省美沙酮门诊就诊者感染丙型肝炎病毒基因型特征分析[J]. 实用预防医学, 2019, 26(4): 500-502.
DAI Jun-bin, WANG Fang-yu, ZOU Xiao-bai, CHEN Xi, HE Jian-mei. Characteristics of HCV genotypes of outpatients in methadone maintenance treatment clinics in Hunan Province. , 2019, 26(4): 500-502.
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2019, Vol. 26 
