Distribution characteristics of single nucleotide polymorphisms of folic acid metabolism pathway key enzyme gene MTHFR C677T among the Han population in Foshan City
GUO Xiao-ling1, LU Yan-qiang2, YANG Xing-kun1, ZHONG Jin1, LIU Dan1, LI Ying2
1.Foshan Maternal and Child Health Care Hospital, Foshan, Guangdong 528000, China; 2.Shanghai Institute of Targeted Therapy and Molecular Medicine, Shanghai 200433, China
Abstract:Objective To investigate the distribution of single nucleotide polymorphisms (SNPs) of folic acid metabolism pathway key enzyme gene methylenetetrahydrofolate reductase (MTHFR) C677T in the Han population in Foshan City. Methods We recruited 182 females and 120 males among the Han population in Foshan City to serve as the research subjects. Gene polymorphisms of MTHFR C677T were detected, and their association with gender and region was analyzed. Results The proportions of MTHFR C677T genotypes CC, CT and TT in 302 Han persons in Foshan City were 62.6%, 31.8% and 5.6% respectively, and the proportions of alleles C and T were 78.5% and 21.5% respectively. No statistically significant difference was found in the distribution of MTHFR C677T genotypes between males and females (P>0.05). The distribution of MTHFR C677T genotypes and alleles in the Han persons in Foshan City was statistically different from the reported data of the Han population in Wuhan, Xi’an, Changzhi, Qingdao, Beijing and Urumqi (P<0.05) as well as that in Hui, Mongolian, Uygur and Miao nationalities (P<0.05), but was not statistically different from that in Buyi nationality (P>0.05). Conclusions The difference is statistically significant in the distribution of MTHFR C677T gene polymorphisms in the Han persons in Foshan City as compared with that in other regions and nationalities. Genetic factors can be taken into account in the implementation of personalized routine health measures.
郭晓玲, 鲁衍强, 杨兴坤, 钟进, 刘丹, 李瑛. 佛山市汉族人群叶酸代谢通路关键酶基因MTHFR C677T多态性分布特征调查[J]. 实用预防医学, 2019, 26(3): 290-292.
GUO Xiao-ling, LU Yan-qiang, YANG Xing-kun, ZHONG Jin, LIU Dan, LI Ying. Distribution characteristics of single nucleotide polymorphisms of folic acid metabolism pathway key enzyme gene MTHFR C677T among the Han population in Foshan City. , 2019, 26(3): 290-292.