Dynamic observation on the levels of blood and urinary cadmium and urinary β2-microgloblin among cadmium-exposed workers in a zinc powder processing factory
LI Ji-meng, HU Wen-wu, ZHANG Bing, GUAN Yu-hong, LUO Zhen-huan, HE Jun, ZHOU Bo, LUO Lei
Changsha Municipal Center for Disease Control and Prevention, Changsha, Hunan 410004, China
Abstract：To explore the changes in urinary cadmium (UCd), blood cadmium (BCd) and urinary β2-microgloblin (Uβ2-MG) levels among low-dose cadmium-exposed workers. Methods We detected the concentration of cadmium in the air of working places of a zinc powder processing factory, and measured cadmium-exposed workers’ UCd, BCd and Uβ2-MG levels for seven consecutive years. Results The M (P25,P75) of BCd in the exposure group (7.05μg/g (3.50μg/g, 11.80μg/g)) was higher than that in the control group (2.84μg/g (0.92μg/g, 7.76μg/g)), showing a statistically difference (P<0.05). The exceeding standard rates of UCd and BCd and the detection rate of fatty liver were also higher in the exposure group than in the control group (24.1% vs. 8.9%, 56.6% vs. 33.3%, 39.8% vs. 22.2%), showing statistically significant differences (all P<0.05). During the 7-year observation period, the median of UCd, BCd and Uβ2-MG in the exposure group fluctuated between 2.74(1.68, 4.29)-4.42(2.88, 6.17) μg/gCr, 3.78(2.08, 5.80)-10.23(3.55, 14.54)μg/g and 250.0(128.6, 449.2)-436.0(366.0, 500.4) μg/gCr respectively, showing statistically significant differences among different years (all P<0.01). The exceeding standard rates of UCd, BCd and Uβ2-MG in the exposure group fluctuated between 15.6%-41.1%, 35.7%-71.4% and 2.4%-27.4% respectively, with statistically significant differences among different years (all P<0.01). No statistically significant difference was observed in the over-standard constituent ratio of UCd level among different years (P>0.05). Conclusions Low-dose exposure to cadmium can affect UCd, BCd and Uβ2-MG levels of cadmium-exposed workers, and the levels of UCd, BCd and Uβ2-MG in these workers show fluctuations
李继猛, 胡文武, 张兵, 官玉红, 罗振华, 何俊, 周波, 罗磊. 某锌粉厂镉作业工人血镉、尿镉、尿β2-微球蛋白动态观察[J]. 实用预防医学, 2018, 25(12): 1438-1440.
LI Ji-meng, HU Wen-wu, ZHANG Bing, GUAN Yu-hong, LUO Zhen-huan, HE Jun, ZHOU Bo, LUO Lei. Dynamic observation on the levels of blood and urinary cadmium and urinary β2-microgloblin among cadmium-exposed workers in a zinc powder processing factory. , 2018, 25(12): 1438-1440.
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2018, Vol. 25 
