Abstract：Objective To explore the species of opportunistic infection pathogens and drug susceptibility Results in patients with AIDS. Methods Bacteria and fungi in blood samples were cultured by BeeT/Alert3D culture system. Most of bacterial strains and their drug susceptibility were identified by VITEK2 COMPACT microbial analyzer, but some strains by manual method. Drug susceptibility testing of fungi was performed with ATB strips.Results There were 34 positive samples among the detected blood samples collected from 164 AIDS patients, and a total of 34 strains of pathogenic bacteria were separated, with the total positive rate being 20.73%. 16 (47.06%) strains of fungi were detected, including 12 (75%) strains ofCyptococcus neoformans, 2 (12.50%) stains of Penicillium marneffei and the other 2 (12.50%) stains which were unidentified due to the death of the patients. 10 (29.41%) strains of Gram-positive coccus were detected, and all of them were coagulase negative staphylococcus (CNS), with 8 strains of methicillin-resistant Staphylococcus haemolyticus (MRSH). 6 (17.65%) strains of Gram-positive rods were detected, and all of them were Nocardia asteroides. 2 (5.88%) strains of Gram-negative bacilli were detected, which were Salmonella paratyphi. The sensitive rates of 12 strains of Cryptococcus neoformans to 5-fluorocytosine, amphotericin B, fluconazole, itraconazole and voriconazole were all 100%. The sensitive rates of 10 strains of Staphylococcus to vancomycin, quinupristin/dalfopristin, linezolid and gentamicin were all 100%, but the resistant rates to erythromycin, penicillin G and clindamycin were all 100%. 6 stains of Nocardia asteroides were sensitive to trimethoprim and gentamicin. Conclusions The opportunistic infection pathogens in patients with AIDS are mainly fungi, especially Cryptococcus neoformans gives priority.
储从家, 吴惠玲. 164例艾滋病患者血液培养病原体分布及耐药性分析[J]. 实用预防医学, 2018, 25(7): 872-873.
CHU Cong-jia, WU Hui-ling. Distribution and drug resistance of blood culture pathogens in 164 patients with AIDS. , 2018, 25(7): 872-873.
2018, Vol. 25 
