Abstract：Objective To explore the correlation between polycystic ovarian syndrome (PCOS) and endometrial cancer (EC) so as to determine whether PCOS might increase the risk of developing EC. Methods We searched Pubmed, the Cochrane Library, Medline, Wanfang, CNKI and other databases, and collected the literature about PCOS in relation to the risk of developing EC. The Newcastle-Ottawa scale (NOS) was used to evaluate the quality of the literature. A meta-analysis was performed to calculate odds ratio (OR) and 95% confidence interval (95%CI) of the included case-control studies by using STATA 12.0 software, and a systematic review of cohort studies were also conducted.Results A total of 442 studies were retrieved, and finally 7 eligible studies (including 4 case-control studies and 3 cohort studies) were included. Meta analysis of case-control studies showed that there was no significant correlation between PCOS and EC (OR=1.82, 95%CI=0.84-3.93, I2=64.6%, P=0.037). Conclusions No significant correlation is found between PCOS and the risk of developing EC based on the current evidence. But the relationship between them is complex and is affected by many factors; and hence, further better-designed studies are still required.
[1] 何晓彤, 孟祥雯, 张雪娇,等.多囊卵巢综合征病因与发病机制的研究进展[J].中国妇幼保健, 2017, 32(7):1588-1591. [2] Pillay OC, Fong LF, Crow JC, et al. The association between polycystic ovaries and endometrial cancer[J]. Hum Reprod, 2005, 21(4):924-929. [3] Vos T, Allen C, Arora M, et al. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015:a systematic analysis for the Global Burden of Disease Study 2015[J]. Lancet, 2016, 388(10053):1545-1602. [4] Hardiman PJ, Pillay OS, Atiomo W, et al. Polycystic ovary syndrome and endometrial carcinoma[J]. Lancet, 2003, 361(9371):1810-1812. [5] Pillay OC, Fong LF, Crow JC, et al. The association between polycystic ovaries and endometrial cancer[J]. Hum Reprod, 2005, 21(4):924-929. [6] Iatrakis G, Zervoudis S, Saviolakis A, et al. Women younger than 50 years with endometrial cancer.[J]. Eur J Gynaecol Oncol, 2006, 27(4):399-400. [7] Zucchetto A, Serraino D, Polesel J, et al. Hormone-related factors and gynecological conditions in relation to endometrial cancer risk[J]. Eur J Cancer Prev, 2009, 18(4):316-321. [8] Brinton LA, Moghissi KS, Westhoff C, et al. Cancer risk among infertile women with androgen excess or menstrual disorders (including polycystic ovary syndrome)[J]. Fertil Steril, 2009, 94(5):1787-1792. [9] Fearnley EJ, Marquart L, Spurdle AB, et al. Polycystic ovary syndrome increases the risk of endometrial cancer in women aged less than 50 years:an Australian case–control study[J]. Cancer Cause Control, 2010, 21(12):2303-2308. [10] Gottschau M, Kjaer SK, Jensen A, et al. Risk of cancer among women with polycystic ovary syndrome:A Danish cohort study[J]. Gynecol Oncol, 2015, 136(1):99-103. [11] Shen C, Yang AC, Hung J, et al. A nationwide population-based retrospective cohort study of the risk of uterine, ovarian and breast cancer in women with polycystic ovary syndrome[J]. Oncologist, 2015, 20(1):45-49. [12] Kaaks R, Berrino F, Key T, et al. Serum sex steroids in premenopausal women and breast cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC)[J]. J Natl Cancer I, 2005, 97(10):755-765. [13] Barry JA, Azizia MM, Hardiman PJ. Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome:a systematic review and meta-analysis[J]. Hum Reprod Update, 2014, 20(5):748-758. [14] Haoula Z, Salman M, Atiomo W. Evaluating the association between endometrial cancer and polycystic ovary syndrome[J]. Hum Reprod, 2012, 27(5):1327-1331. [15] Wild S, Pierpoint T, Jacobs H,et al. Long-term consequences of polycystic ovary syndrome:results of a 31 year follow-up study[J]. Hum Fertil (Camb), 2000, 3(2):101-105. [16] Lim S, Davies MJ, Norman RJ,et al. Overweight, obesity and central obesity in women with polycystic ovary syndrome:a systematic review and meta-analysis[J]. Hum Reprod Update, 2012, 18(6):618-637. [17] Saso S, Chatterjee J, Georgiou E, et al. Endometrial cancer[J]. Bmj-Brit Med J, 2011, 343(1):84-89. [18] 顾艳伟. 二甲双胍联合短效避孕药对多囊卵巢综合征患者内分泌和血脂影响研究[J]. 实用预防医学, 2015, 22(10):1254-1255. [19] Allen N, Peto R, Beral V, et al. Endometrial cancer and oral contraceptives: an individual participant meta-analysis of 27 276 women with endometrial cancer from 36 epidemiological studies[J]. Lancet Oncol, 2015, 16(9):1061-1070.
2018, Vol. 25 
