Abstract:Objective To investigate the epidemiological characteristics and genotypes of rotavirus in diarrhea children below 5 years old in Hebei Province during 2012-2016. Methods We collected 1,614 stool samples from diarrhea children aged 0-59 months in viral diarrhea sentinel hospitals in Hebei Province from January 2012 to December 2016. Rotavirus antigen was detected by ELISA, and then the positive samples were genotyped by RT-PCR. SPSS 20.0 software was used to analyze the infectious status and epidemiological characteristics of rotavirus in diarrhea children.Results The positive rate of rotavirus antigen was 45.23% (730/1,614). The rotavirus infection rates of males and females were 42.96% (412/959) and 48.55% (318/655), showing a statistically significant difference (χ2=4.906, P=0.027). Rotavirus infection showed a clearly seasonal distribution, and the detection rate of rotavirus diarrhea was found to be the highest in autumn and winter (from November to next March). Rotavirus infection occurred in children ranging in age from 0 to 59 months, but 96.44% of the cases were children aged 3-35 months. It tended to firstly increase then decrease with the increasing age. There were statistically significant differences in the positive rate of rotavirus antigen among children from different age groups (χ2=94.369, P=0.000). Among the 730 samples positive for rotavirus antigen during 2012-2016, the predominant genotype was G9 and its proportion showed an increasing tendency year-by-year. P[8] was found as predominant genotype. The major rotavirus strain was G9P[8] (70.14%), followed by G2P[4] (7.53%). Conclusions Rotavirus was the main pathogen causing viral diarrhea among children under 5 years old in Hebei Province during 2012-2016. The incidence of rotavirus-related diarrhea peaked in fall and winter, and genotype G9P[8] was identified as the most prevalent strain.
赵文娜, 于秋丽, 刘莹莹, 苏通, 谢赟, 齐顺祥. 2012-2016年河北省5岁以下腹泻患儿轮状病毒感染情况及流行特征分析[J]. 实用预防医学, 2018, 25(7): 777-779.
ZHAO Wen-na, YU Qiu-li, LIU Ying-ying, SU Tong, XIE Yun, QI Shun-xiang. Infectious status and epidemiological characteristics of rotavirus amongdiarrhea children under 5 years old in Hebei Province, 2012-2016. , 2018, 25(7): 777-779.