Abstract：Objective To investigate the epidemiological features of hand-foot-mouth disease (HMFD) among children aged 5 years and below in Jilin Province during 2012-2016, and to provide a scientific basis for formulating targeted prevention and control measures based on susceptible people. Methods Descriptive epidemiological method was used to analyze the data collected from Communicable Disease Reporting Information Management System and concerning HMFD incidence among children aged 5 years and below in Jilin Province from 2012 to 2016. Results A total of 55,352 HMFD cases aged 5 years and below were accumulatively reported in Jilin Province during 2012-2016, with the annual average incidence rate being 870.13/100,000. HMFD had a peak incidence every two years, and most of the cases occurred in June-August, with a single peak distribution. The incidence rates in Yanbian Autonomous Prefecture (1,867.88/100,000), Tonghua City (1,342.02/100,000) and Jilin City (1,030.50/100,000) ranked the top three. Among different age groups, the incidence rates of HMFD were all higher in males than in females (all P<0.01). The sex ratio of male and female cases was 1.45:1. Most of the cases were scattered children (accounting for 69.15%), and the annual average incidence rate of HMFD in the age group of 2 years was found to be the highest. Among the samples tested positive for enterovirus, the other intestinal viruses, CoxA16 and EV71 accounted for 39.56%, 30.79% and 29.66% respectively. Among the enterovirus-positive samples collected from severe cases, EV71 accounted for 79.02%. Conclusions The incidence of HMFD among children aged 5 years and below in Jilin Province from 2012 to 2016 showed significant epidemiological characteristics of season, region and susceptible popoulation. EV71, CoxA16 and the other intestinal viruses causing HMFD epidemics presented an alternating dominant feature, but the other intestinal viruses became the predominant pathogen in recent two years. Severe and fatal cases were mainly infected with EV71.
2018, Vol. 25 
