Abstract：Objective To explore the relationship between serum amyloid A (SAA), brain derived neurotrophic factor (BDNF), alkaline phosphatase (ALP) and vascular cognitive impairment after stroke. Methods One hundred and sixty-seven patients with stroke were selected from Affiliated Hospital of Panzhihua University from February 2015 to February 2017. According to the Mini-Mental State Examination (MMSE), 71 patients with cognitive impairment (serving as the observation group) and 96 patients with normal cognition (serving as the control group) were detected. Serum levels of SAA, BDNF and ALP were detected and compared between the two groups; meanwhile, age, gender and other clinical information as well as serum levels of SAA, BDNF and ALP of patients with different degrees of cognitive impairment in the two groups were also compared. Results No statistically significant differences were found in gender, age, education years, basic diseases, smoking, the number of lesions and the injuried part between the observation group and the control group (all P<0.05). Serum levels of SAA and ALP were significantly higher in the observation group than in the control group ((1.80±0.61) mg/L vs. (0.49±0.12) mg/L, (90.41±8.16) U/L vs. (60.22±9.04)U/L), while serum level of BDNF was significantly lower in the observation group than in the control group ((4.68±1.06) ng/mL vs. (5.51±1.13) ng/mL), showing statistically significant differences (all P<0.05). Serum levels of SSA and ALP were both significantly higher in patients with severe cognitive impairment than in ones with mild and moderate, while serum level of BDNF was significantly lower in patients with severe cognitive impairment than in ones with mild and moderate, showing statistically significant differences (all P<0.05). Serum levels of SSA and ALP were both significantly higher in patients with moderate cognitive impairment with mild, but serum level of BDNF was significantly lower in patients with moderate cognitive impairment than in ones with mild, showing statistically significant differences (all P<0.05). Serum SAA and ALP were negatively correlated with MMSE score (r=-0.413, r=-0.402, P<0.05), while BDNF was positively correlated with MMSE score (r=0.341, P<0.05). Conclusions Serum levels of SAA, BDNF and ALP are associated with vascular cognitive impairment after stroke, which is worthy of further study.
2018, Vol. 25 
