Abstract： Objetive To analyze the etiological characteristics of hand-foot-mouth disease (HFMD) in Fengchenggang city during 2010-2015, and provide a basis for further prevention and control of HFMD. Methods Etiological surveillance data of HFMD in Fangchenggang City in 2010-2015 were collected and were analyzed by descriptive epidemiological methods. Results A total of 1,405 samples of HFMD cases were detected and 703 were general enterovirus nuclear acids positive, with a detection rate of 50.04%(703/1,504).Of the 703 cases, 22.19% (156/703) were infected with enterovirus 71(EV71), 19.20% (135/703) with Coxackievirus A16 (CoxA16), and 58.61% (412/703) with other enterovirus. EV71 was the major pathogen (62.90%, 39/62) in 2011, while the other enterovirus were predominant in the other 5 years, 70.73% (72/99) in 2010, 45.38% (54/119) in 2012, 76.65% (151/197) in 2013, 43.86% (75/171) in 2014, and 83.64% (46/55) in 2015. The dominant pathogen were different each month,CoxA16 in February, EV71 in April and other EV in the other months. For the monitoring cases and positive cases, the male to female ratios were 1.67:1 and 2.04:1 respectively. The surveillance cases (87.47%, 1,229/1,405) and positive cases (90.19%,634/703) mainly concentrated in the children under the age of 4 years. The cases distributed in all the counties (cities, districts). The incidence of severe cases caused by EV71 (16.03%, 25/156) was higher than that caused by the other enterovirus (6.31%, 26/412) and by CoxA16 (0.74%, 1/135) , with significant difference (χ2=43.62,P<0.001). The detection rates of various pathogens from anal swab specimen (54.52%) were higher than those from pharyngeal swab specimens(24.40%) ,showing statistical difference (χ2=64.53,P<0.001). Conclusions HFMD mainly does harm to children under 5 years old in Fengchenggang city. The other EV is the major pathogen. EV71 is more easier to lead to severe cases than CoxA16 and other enterovirus.
2018, Vol. 25 
