Abstract： Objective To investigate the immunological effect of highly active anti-retroviral therapy (HAART) on AIDS and its influencing factors in Zhuhai City. Methods Retrospective survey method was used in this study. We selected all AIDS patients who had received initial HAART for at least half a year and accepted the detection of CD4+T lymphocyte count before and after receiving HAART in Zhuhai City during 2005-2014 to serve as the research objects. The immunological effect of HAART was evaluated on the basis of the count of CD4+T lymphocytes. Multifactor logistic regression analysis was performed to identify factors afffecting the effect of HARRT. Results There were 265 cases with effective HAART among 309 surveyed AIDS patients, with the effective rate being 85.8%. The amount of CD4+T lymphocytes in the AIDS patients after the treatment was significantly increased as compared with that before the treatment ((309.74±175.42)vs. (165.67±108.36), t=20.13, P<0.01). The Results of multifactor logistic regression analysis showed that the effective rate of immunological responses to HAART was significantly higher in the cases in clinical stages Ⅰ (OR=7.755), Ⅱ (OR=18.338) and Ⅲ (OR=1.369) than in the cases in clinical stage Ⅳ as well as higher in the cases with good medicine compliance than in the cases with poor medicine adherence (OR=3.741). Conclusions The therapeutic effect of HAART among the AIDS patients in Zhuhai City is obvious. The patients' clinical stages and medicine compliance are the leading factors influencing the therapeutic effect. Early clinical stages and good medicine compliance are conducive to acquiring satisfactory immunological effect of treatment. The Results suggest that early detection, early treatment and good medicine compliance are beneficial to further improving therapeutic effect of HAART on AIDS in Zhuhai City.
姚刚, 朱克京, 杜曼, 周毅. 珠海市艾滋病患者高效抗逆转录病毒治疗免疫学效果及影响因素分析[J]. 实用预防医学, 2018, 25(3): 294-296.
YAO Gang, ZHU Ke-jing, DU Man, ZHOU Yi. Immunological effect of highly active anti-retroviral therapy and its influencing factors among AIDS patients in Zhuhai City. , 2018, 25(3): 294-296.
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2018, Vol. 25 
