Abstract：Objective To explore the expression levels and clinical significance of serum N-terminal pro-brain natriuretic peptide (NT-proBNP) and interleukin-6 (IL-6) in children with Kawasaki disease (KD). Methods Children with KD who were hospitalized in Cangzhou Central Hospital from August 2014 to December 2016 served as the case group (n=50), and then they were divided into coronary artery injury group (n=17) and non-coronary artery injury group (n=33) according to the coronary artery injury. At the same time, non-KD children who were hospitalized for febrile disease were selected as the control group (n=50). The serum NT-proBNP levels were detected by electrochemiluminescence, and the serum IL-6 levels were determined by enzyme-linked immunosorbent assay. Results The serum NT-proBNP and IL-6 levels in the case group were both higher than those in the control group, showing a statistically significant difference (P<0.05). The serum NT-proBNP and IL-6 levels were both higher in coronary artery injury group than in non-coronary artery injury group, with statistically significant differences (P<0.05). Pearson's product-moment correlation analysis showed that serum NT-proBNP was positively correlated with IL-6 in the case group (r=0.639, P<0.05). According to the receiver operating characteristic curve (ROC) analysis, the area under ROC curve (AUC) of NT-pro BNP for detection of KD was 0.862(95%CI:0.755-0.970), and the optimal cut-off value, sensitivity and specificity were 1.07 ug/L, 89.21% and 92.24% respectively. The AUC of IL-6 for detection of KD was 0.904 (95%CI:0.813-0.995), and the optimal cut-off value, sensitivity and specificity were 58.21 ng/ml, 93.41% and 89.16% respectively. The AUC of NT-proBNP combined with IL-6 for detection of KD was 0.915 (95%CI:0.837-0.993), with the sensitivity and specificity being 96.27% and 92.24% respectively. Conclusions The serum NT-proBNP and IL-6 in children with KD are significantly increased; and hence, early detection of serum NT-proBNP combined with IL-6 can be used as the important indexes for auxiliary diagnosis of KD.
江雅静, 赵玉岐, 王鹤, 钱程, 刘昱. 血清NT-proBNP与IL-6在川崎病患儿中的水平变化及临床意义[J]. 实用预防医学, 2018, 25(2): 199-201.
JIANG Ya-jing, ZHAO Yu-qi, WANG He, QIAN Cheng, LIU Yu. Changes and clinical significance of serum NT-proBNP and IL-6 levels in children with Kawasaki disease. , 2018, 25(2): 199-201.
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2018, Vol. 25 
