Abstract：Objective To explore the correlation between serum visfatin and myeloperoxidase levels and the formation and stability of carotid atherosclerosis plaques in patients with ischemic stroke. Methods One hundred and thirty-nine ischemic stroke patients hospitalized in Department of Neurology, the Pepole’s Hospital of Taoyuan County, Changde City from March 2015 to June 2016 were selected as the research objects; meanwhile, 65 individuals with healthy check-up Results reported by the hospital served as the controls. Their serum levels of visfatin and myeloperoxidase were determined by enzyme-linked immunosorbent assay. We collected their clinical data and results of carotid ultrasound scan, and then calculated Crouse integral of carotid plaques. Results The serum levels of visfatin and myeloperoxidase were significantly higher in patients with ischemic stroke than in the controls (P<0.01); moreover, the serum visfatin and myeloperoxidase levels and Crouse integral were significantly higher in the plaque destabilization group than in the stable plaque group as well as the non-plaque group (all P<0.01). The serum levels of visfatin and myeloperoxidase in patients with ischemic stroke were positively correlated with the Crouse integral of carotid plaques(r=0.796, P<0.01; r=0.723, P<0.01). Multivariate linear regression analysis showed that the serum levels of visfatin(OR=1.42,95%CI:1.15-1.75,P= 0.0011), MPO(OR=1.08 ,95%CI:1.03-1.13 ,P=0.0015 ), LP(a) (OR=1.11,95%CI:1.02-1.21,P=0.0156), LDL-C(OR=2.13,95%CI:1.25-3.63,P=0.0054), hypertension(OR=1.98,95%CI:1.13-3.45,P=0.0201), diabetes(OR=1.23,95%CI:1.02-1.48,P=0.0302) and age(OR=1.95,95%CI:1.11-3.43, P=0.0202) were the independent risk factors affecting plaque stability of patients with ischemic stroke. Conclusions The serum levels of visfatin and myeloperoxidase in patients with ischemic stroke are closely correlated with the formation and stability of carotid artery intimal plaque; and hence, it is of an important clinical significance to prevention, monitoring and treatment of ischemic stroke with detecting the serum levels of visfatin and myeloperoxidase.
文锟, 徐平, 胡兴国, 王明建, 洪云军, 雷鸣. 缺血性脑卒中患者血清内脂素和髓过氧化物酶水平与颈动脉粥样硬化关系的研究[J]. 实用预防医学, 2018, 25(1): 62-65.
WEN Kun, XU Ping, HU Xing-guo, WANG Ming-jian, HONG Yun-jun, LEI Ming. Relationship of serum visfatin and myeloperoxidase levels and carotid atherosclerosis in patients with ischemic stroke. , 2018, 25(1): 62-65.
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2018, Vol. 25 
