Abstract：Objective To study the clinical situation of embryo abnormal karyotype in 720 cases of early spontaneous abortion(SA). Methods We retrospectively analyzed 720 early SA patients hospitalized in Northwest Women's and Children's Hospital from January 2013 to December 2016. The related data of the patients were recorded, and then performed statistical analysis of karyotypes from SA embryos, abnormal karyotypes from aneuploid embryos in SA and the relationship between abortion age, abortion frequency and embryo karyotype. Results The proportion of abnormal karyotypes from SA embryos was 58.61%, while that of normal karyotypes from SA embryos was 41.39%. The aneuploid was the most common type of abnormal karyotypes, accounting for 39.72%. Among abnormal karyotypes from aneuploid embryos in SA, +16 type was identified in 62 (21.68%) cases, +22 type in 44 (15.38%) cases and (45, X) type in 40 (13.99%) cases. The proportions of abnormal embryo karyotypes and aneuploid were both significantly higher in patients aged ≥ 36 years than in patients aged ＜36 years, while the proportion of normal karyotype was significantly lower in patients aged ≥ 36 years than in patients aged ＜36 years, showing statistically significant differences (all P<0.05). The proportions of abnormal karyotypes and chromosome structure abnormality were significantly higher in patients with SA for ＞ 2 times than in patients with SA for ≤ 2 times, while the proportion of aneuploid was significantly lower in patients with SA for ＞ 2 times than in patients with SA for ≤ 2 times, with statistically significant differences (all P<0.05). Conclusion The embryo abnormal karyotypes are found to represent the main cause of SA, and the abnormal karyotype of aneuploid is the commonest; moreover, the patients’ abortion age and abortion frequency are related to the embryo karyotypes.
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2017, Vol. 24 
