Abstract：Objective To investigate the nasopharyngeal carriage of Haemophilus influenzae type b and its drug resistance in healthy infants aged 12-18 months in Dongguan City so as to provide referential evidence for formulating prevention strategies. Methods A total of 598 nasopharyngeal swabs were collected from healthy infants aged 12-18 months in 5 towns of Dongguan City in early summer (from May to June in 2009) and winter (in January, 2010). Haemophilus influenzae culture was performed and its antimicrobial resistance was detected. Results The nasopharyngeal carrying rate of Haemophilus influenzae type b in healthy infants aged 12-18 months in Dongguan City was 5.35%(32/598). The living unit which was < 20m3/person was the risk factor for Haemophilus influenzae type b infection (OR=3.420, 95%CI:1.449-8.074,). The vaccination coverage rate of Haemophilus influenzae type b was 60.37% (361/598). 3 strains ofHaemophilus influenzae type b were detected to be resistant to ampicillin, accounting for 12.00% of the total isolated strains (3/25). Conclusions Small living unit will increase the risk of Haemophilus influenzae type b infection. It is suggested to advocate healthy lifestyle to improve the infants’ living environment. Increasing the vaccination rate of Haemophilus influenzae type b vaccine is conducive to decreasing its nasopharyngeal carrying rate in infants.
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2017, Vol. 24 
