Abstract：Objective To analyze the incidence rate of liver cancer and its changing trend in Chongqing so as to provide suggestions for liver cancer prevention and control. Methods The data regarding liver cancer cases from 11 cancer registration sites in Chongqing during 2006-2015 were sorted by the international category of disease (ICD-10), and then statistically analyzed by SPSS 19.0 software. The indicators, such as the incidence rate, age-standardized incidence rate by Chinese standard population (ASIRC), annual percent change (APC), truncated rate and cumulative risk were calculated. The trend changes of incidence were identified by curve estimated exponential distribution regression model. The incidence rates between males and females, urban and rural areas were compared by Chi-square test. Results The incidence rate of liver cancer in Chongqing increased from 18.39/100,000 in 2006 to 30.63/100,000 in 2015, and no statistically significant difference was found in the changing trend (F=3.04,P=0.119). The ASIRC increased from 16.32/100,000 in 2006 to 18.30/100,000 in 2015, but the APC was -0.90%, and the changing trend showed no statistically significant difference (F=0.38, P=0.555). The incidence rate of liver cancer in each year during 2006-2015 was higher in males than in females (P<0.001). The female ASIRC of liver cancer decreased from 10.50/100,000 in 2006 to 9.15/100,000 in 2015, and the APC was -4.50%, showing statistically significant difference in the changing trend (F=7.93, P=0.023). The incidence rate of liver cancer increased with the increasing age. It was below 10/100,000 for the age group <40 years old and increased rapidly for the age group >40 years old, reaching the top in the age group of 85- years. The incidence rates of liver cancer in the age groups of 45- and 60- years showed an upward trend, and their APCs were 7.79% and 3.87% respectively, showing statistically significant differences in the changing trend (F=8.50, P=0.019; F=13.63, P=0.006). The truncated rate increased from 23.74/100,000 in 2006 to 34.53/100,000 in 2015, and the APC was 3.77%, showing statistically significant differences in the changing trend (F=7.71, P=0.024). The cumulative risk increasedfrom 0.35% in 2006 to 0.41% in 2015, and the APC was 2.94%, showing statistically significant differences in the changing trend(F=7.05, P=0.029). The cumulative risk was higher in males than in females, with a statistically significant difference (P<0.05). Conclusions The incidence rates of liver cancer in Chongqing during 2006-2015 showed a gradually increasing tendency, so did the cumulative risk; and hence, it is necessary to enhance the study of factors related to liver cancer and its prevention and treatment.
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