A study of nanometer-Pb on the serum immunoglobulin contents and T lymphocyte subsets in mice
ZHOU Yong1,LIU Yu1,HE Jun-shan1,ZHANG Hong-mei2
1 Department of preventive medicine,Xiang Nan University,Chen zhou Hunan 423000,China; 2 Chen zhou center of disease prevention and control,Chen zhou Hunan 423000,China
Abstract：[Objective] To examine the effect of immune function caused by nano-Pb.[Methods] 80 mice were randomly divided into five groups includeing one control group and four exposure groups(low-dose group,middle dose group,high dose group and common PbO2 group). They received different dose of nano-PbO2 by gavage for five days continuously, the serum immunoglobulin contents and T lymphocyte subsets were measured. [Results] The serum immunoglobulin G,E,M,and the percentage of the CD4+ T lymphocyte,and the ratio of CD4+/CD8+ T lymphocyte of the mice in nano-PbO2 groups were lower than that in contrast groups （P<0.05）,and the combined toxicity effects to the immunological function were significantly different with those effects of individual toxicity（P<0.05）,and the immune index were the lowest in high dose nano-PbO2 group（P<0.05）. At the same trearment dose,the immune index of mice in nano-PbO2 group were significantly higher than that of the common PbO2 group(P <0.05). [Conclusion] This study indicates that nanometer-Pb could damage the immune function of mice,and the adverse effects above induced by nano- PbO2 were distinctly stronger than that of the common PbO2.
周勇,刘瑜,何军山,张红梅. 纳米级铅对小鼠免疫球蛋白和T淋巴细胞亚型影响的研究[J]. 实用预防医学, 2015, 22(7): 781-782.
ZHOU Yong,LIU Yu,HE Jun-shan,ZHANG Hong-mei. A study of nanometer-Pb on the serum immunoglobulin contents and T lymphocyte subsets in mice. , 2015, 22(7): 781-782.
2015, Vol. 22 
