Abstract：ObjectiveTo assess the association of TGF-β1 gene SNPs -509C>T, Leu10Pro(T>C) and Arg25Pro(G>C) with genetic susceptibility to liver fibrosis. MethodsPubMed, CNKI were searched using search terms: “liver cirrhosis” (MeSH), “Transforming Growth Factor beta1” (MeSH), and key words “liver Fibrosis”, “TGF-β1”, “gan ying hua(Chinese)”. The studies on the relationship between TGF-β1 polymorphisms and susceptibility to liver fibrosis were collected. RevMan5.2 and STATA12 were used to compute the value of pooled odds ratio(OR) or rate ratio(RR), subgroup analysis, sensitivity analysis, and heterogeneity test. The effect of publication bias was evaluated, using the method of funnel plot and Egger test. Results There were 17 case-control studies with 2043 liver fibrosis cases and 2316 controls for liver fibrosis susceptibility related to TGF-β1 gene polymorphisms. Meta analysis showed that the -509C>T C allele decreased the risk of liver fibrosis (C vs T, OR=0.820,95%CI:0.728-0.923, P=0.001;CC+CT vs TT, OR=0.826,95%CI: 0.689 -0.990, P=0.039;CC vs CT+TT, OR=0.731,95%CI: 0.600 -0.891, P=0.002;CC vs TT, OR=0.711,95%CI: 0.567 -0.893, P=0.003). Leu10Pro(T>C) did not show any statistically significant association with liver fibrosis(P>0.05) . Arg25Pro(G>C) G allele decreased the risk of liver fibrosis (G vs C, OR=0.063,95%CI:0.049-0.080, P=0.000; GG vs GC+CC, OR=0.600,95%CI: 0.441 -0.816, P=0.001). Conclusions The meta-analysis showed a significant association between TGF-β1 -509(C>T) C allele and/or Arg25Pro (G>C) G allele and decreased risk of liver fibrosis, it displayed these alleles were protection factors to liver fibrosis.
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2015, Vol. 22 
