摘要 目的探讨SDF1-3’A和CCR2-64I基因的多态性与HIV-1感染之间的关联性。方法检索国内外有关SDF1-3’A和CCR2-64I基因的多态性与HIV感染相关性的病例对照研究文献进行Meta分析。结果符合CCR2-64I入选条件的文献有13篇,20个研究,总共有5578例样本,其中病例有2898例,健康对照有2680例,当CCR2-64I基因所入选的研究全部合并在一起时,在所有模型中没有发现其显著相关性（CY vs. CC: OR = 0.97,95% CI = 0.85-1.09; CY + YY vs. YY: OR = 1.00,95% CI = 0.89-1.13;YY vs. CC：OR = 1.28,95% CI = 0.97-1.69）。符合SDF1-3’A入选条件的文献13篇,19个研究,总共有4854例,其中病例有2281例,健康对照有2573例,在整个和亚组分析中没有发现其显著相关性。而在印度人群发现高度的异质性。结论亚洲人群CCR2-64I两种抗性基因与HIV-1感染之间无相关性;中国人群SDF1-3’A与HIV-1感染之间无相关性;印度人群SDF1-3’A与HIV-1感染之间是否有相关性仍需作进一步的研究。
Abstract：Objective To explore the association of SDF1-3’A and CCR2-64I gene polymorphisms and susceptibility to HIV-1 infection in Asians. Methods Meta-analysis was conducted to identify all case-control studies of SDF1-3’A and CCR2-64I gene polymorphisms by searching domestic and international literature. Results. There were 13 articles involving CCR2-64I which included 20 studies, and 5578 subjects including 2898 cases and 2680 health controls were enrolled in CCR2-64I gene polymorphism. No significant association was found in any genetic model when all the eligible studies was pooled into meta-analysis of CCR2-64I (CY vs. CC: OR = 0.97,95% CI = 0.85-1.09; CY + YY vs. YY: OR = 1.00,95% CI = 0.89-1.13;YY vs. CC：OR = 1.28,95% CI = 0.97-1.69). There were 13 articles involving SDF1-3’A which included 19 studies, and 4854 subjects including 2281 cases and 2573 health controls were enrolled in SDF1-3’A gene polymorphism. No significant association was found in overall analysis and any subgroup analysis. High between- heterogeneity was found in Indians. Conclusions The meta-analysis suggests CCR2-64I polymorphism may be not associated with HIV-1-infected risk in Asians, SDF1-3’A polymorphism may be not associated with HIV-1-infected risk in Chinese. In addition, our work also points out the importance of new studies for SDF1-3’A in Indians.
苏威武, 袁泉, 贺小峰, 刘杨. 亚洲人群中SDF1-3’A和CCR2-64I基因的多态性与HIV-1感染相关性的Meta分析[J]. 实用预防医学, 2016, 23(1): 35-38.
SU Wei-wu*, YUAN Quan, HE Xiao-feng, LIU Yang. The association of SDF1-3’A and CCR2-64I genepolymorphism and HIV-1 infection: Meta-analysis based on case-control study in Asians. , 2016, 23(1): 35-38.
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