Abstract:Objective To evaluate the correlation of mtDNA4977 and presbyacusis using meta-analysis. Methods Databases including PubMed,Embase,CBM,CNKI,WanFang Data,WanFang Med and VIP were searched to collect case-control study on the correlation of mtDNA4977 and presbyacusis,according to the inclusion criteria,collecting the research findings of related articles and conducting a statistic analysis. Results A total of six studies were included in the meta-analysis. The results of meta-analysis showed that the persons with mtDNA4977 deletion had an increased risk of presbyacusis (OR=7.19,95%CI:2.90~17.85) and the difference was statistically significant (P<0.0001). Conclusions MtDNA4977 deletion is related to presbyacusis.
王致, 荣幸, 邹文英, 陶志民, 梁嘉斌, 刘移民. mtDNA4977缺失与老年性聋关系的Meta分析[J]. 实用预防医学, 2016, 23(3): 264-266.
WANG Zhi, RONG Xing, ZOU Wen-ying, Tao Zhi-min, LIANG Jia-bin, LIU Yi-min. Correlation of mitochondrial DNA 4977 bp deletion and presbyacusis: a meta-analysis. , 2016, 23(3): 264-266.
[1] Pearlman RC. Presbycusis: the need for a clinical definition[J]. Am J Otol, 1982, 3(3): 183-186. [2] 盛芩蕙,赵雪莉,黄鹤年. 老年性聋与动脉粥样硬化[J]. 中华耳鼻咽喉科杂志,1983,18:238-239. [3] Fischel-Ghodsian N, Bykhovskaya Y, Taylor.K, et al. Temporal bone analysis of patients with presbycusis reveals high frequency of mitochondrial mutations[J]. Hear Res, 1997, 110(1-2): 147-154. [4] Wei YH. Oxidative stress and mitochondrial DNA mutations in human aging[J]. Proc Soc Exp Biol Med, 1998, 217(1): 53-63. [5] Gholinezhad Chari M, Hosseinzadeh Colagar A, Bidmeshkipour A. A Novel Large-Scale Deletion of The Mitochondrial DNA of Spermatozoa of Men in North Iran[J]. Int J Fertil Steril. 2015, 8(4): 453-463. [6] Zhong Y, Hu Y J, Yang Y, et al. Contribution of common deletion to total deletion burden in mitochondrial DNA from inner ear of d-galactose-induced aging rats[J]. Mutat Res, 2011, 712(1-2): 11-19. [7] 付四清,陈观明. 老年耳聋的线粒体DNA 4977 缺失研究[J]. 中国老年学杂志,2007,27(22): 2209-2210. [8] 韩维举,韩东一,姜泗长,等. 人听觉器官线粒体DNA 4977 缺失与老年聋的关系[J]. 中华耳鼻咽喉科杂志,2000,35(6):416-417. [9] Dai P, Yang W, Jiang S, et al. Correlation of cochlear blood supply with mitochondrial DNA common deletion in presbyacusis[J]. Acta Otolaryngol, 2004, 124 (2): 130-136. [10] Liu H, Han Y, Wang S, et al. Association between the mitochondrial DNA 4977 common deletion in the hair shft and hearing loss in presbycusis[J]. Mol Med Rep, 2015, 11(2): 1127-1131. [11] Bai U, Seidman MD, Hinojosa R, et al. Mitochondrial DNA deletions associated with aging and possibly presbycusis: a human archival temporal bone study[J]. Am J Otol, 1997, 18(4): 449-453. [12] Seidman MD, Bai U, Khan MJ, et al. Association of mitochondrial DNA delections and cochlear pathology: a molecular biologi tool[J]. Laryngoscope, 1996, 106(6): 777-783. [13] Brierley EJ, Johnson MA, Lightowlers RN, et al. Role of mitochondrial DNA mutations in human aging: implications for the central nervous system and muscle[J]. Ann Neurol, 1998, 43(2): 217-231. [14] Yamasoba T, Someya S, Yamada C, et al. Role of mitochondrial dysfunction and mitochondrial DNA mutations in age-related hearing loss[J]. Hear Res, 2007, 226(1-2): 185-193. [15] Markaryan A, Nelson EG, Hinojosa R. Quantification of the mitochondrial DNA common deletion in presbycusis[J]. Laryngoscope, 2009, 119(6): 1184-1189. [16] 戴朴,姜泗长,顾锐,等. 内耳缺血及线粒体DNA缺失与老年性耳聋发病的关系[J]. 中华医学杂志, 2000,80(12):897-900. [17] 刘红. 毛干中线粒体DNA4977bp缺失突变与老年性聋功能损害程度的关系[D]. 山东:山东大学,2014. [18] 吴迪,胡建安, 柳袆. 我国职业性噪声与高血压关系的研究: Meta分析[J]. 实用预防医学,2014,21(12):1464-1467.