Abstract：Objective To explore the correlation between dietary intake of antioxidants and cerebral stroke (CS). Methods We electronically searched databases including PubMed, Web of Science, the Cochrane Library, Embase, CNKI, WanFang, and VIP for literatures about randomized controlled trials (RCTs) on dietary supplementation with antioxidants and CS from January 2000 to January 2022. The effective data were extracted by two researchers, and then bias risks were evaluated. A meta-analysis was conducted by using RevMan 5.3 software. Results A total of 24 articles involving 28 RCTs were included. Meta-analysis results showed that dietary supplementation with total antioxidants could not significantly decrease the risk of CS (OR=1.04, 95%CI:0.98-1.09; Z=1.29, P=0.20>0.05); meanwhile, supplementation with single antioxidant like β-carotene (OR=1.08, 95%CI:0.94-1.25; Z=1.12, P=0.26>0.05), vitamin B (OR=1.02, 95%CI:0.73-1.42; Z=0.11, P=0.91>0.05), vitamin C (OR=0.92, 95%CI:0.77-1.09; Z=0.95, P=0.34>0.05), vitamin D (OR=1.11, 95%CI:0.96-1.29; Z=1.39, P=0.16>0.05) and vitamin E (OR=1.06, 95%CI:0.94-1.20; Z=0.94, P=0.35>0.05) also could not bring down the risk of CS. There was no significant publication bias detected in the meta-analysis (Z=1.41, P=0.158>0.05). Conclusion Available studies suggest that dietary supplementation with antioxidants can not reduce the risk of CS.
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2023, Vol. 30 
