Roles of MPO and SOD in the diagnosis and prognostic assessment of stroke
WU Yuanyuan1,2, ZHU Qing1,2, WU Ying1,2, REN Biqiong1,2, ZOU Guoying1,2
1. Department of Laboratory Teaching and Research, Clinical Medicine School of Hunan University of Chinese Medicine, Changsha, Hunan 410208, China; 2. Brain Hospital of Hunan Province, Changsha, Hunan 410007, China
Abstract：Objective To explore the changes of myeloperoxidase (MPO) and superoxide dismutase (SOD) levels during the progression of stroke patients and the roles of them in prognosis evaluation. Methods We selected 55 stroke patients (including 42 patients with ischemic stroke and 13 patients with hemorrhagic stroke) hospitalized in Brain Hospital of Hunan Province from September 2021 to April 2022 to serve as the research subjects. Serum samples on 5 days after admission were collected and tracked, and then detected the levels of MPO and SOD. We statistically analyzed the roles of daily levels of MPO and SOD on evaluating the severity and prognosis of stroke. The ROC curve was used to analyze the efficacy of the stroke patients' MPO and SOD levels on the day of admission for early diagnosis of stroke. Results Compared with the healthy control group, the stroke patients' serum levels of MPO and SOD on the day of admission significantly decreased (P<0.01). The analysis results based on the ROC curve displayed that the area under the curves (AUCs) of MPO and SOD for predicting stroke were 0.9921 and 0.8408 respectively. Surveillance on the changes in the serum level of MPO revealed that the severity of stroke in the patients was correlated with the increase in the serum level of MPO on the second day after admission (P<0.01); moreover, the higher the increase in MPO, the poorer the prognosis of the patients (P=0.006). Surveillance on the changes in the serum level of SOD exhibited that the prognoses of the stroke patients were related to the serum level of SOD on the day of admission (P=0.017). Conclusion Serum MPO and SOD can provide reference values for early diagnosis and severity assessment of stroke.
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2023, Vol. 30 
