Clinical characteristics of coronavirus disease 2019 in Hunan province
DAI Zhi-hui, GAO Li-dong, LUO Kai-wei, XIAO Jie-hua, HUANG Chao-yang, ZENG Ge, LIU Zi-yan, ZHAO Shan-lu, YANG Hao, SUN Qian-lai, ZHANG Heng-jiao, WANG Juan, HU Shi-xiong
Hunan Provincial Center for Disease Control and Prevention, Changsha, Hunan 410005, China
Abstract:Objective To analyze the clinical characteristics of coronavirus disease 2019 (COVID-19) in Hunan province so as to provide a scientific basis for discovery, treatment and prevention of COVID-19 cases. Methods We retrospectively analyzed the clinical data about all confirmed cases of COVID-19 in Hunan province from January 21, 2020 to February 13, 2020, and then compared the differences in the results of clinical manifestations, laboratory examination and chest computed tomography (CT) scan of patients with different ages and clinical types. Results The high incidence age of 918 patients was 15-64 years old, with 28 patients younger than 15 years old (only accounting for 3.05%). There were 318 (34.64%) mild cases, 523 (56.97%) ordinary cases, 70 (7.63%) severe cases and 7 (0.76%) critical cases. 240 (26.14%) cases had more than one underlying disease. The main clinical manifestations were fever (67.54%) and dry cough (42.59%), with fatigue, expectoration, cough and headache in some patients. The total number of leukocytes in blood routine examination was mainly decreased or normal (97.37%), the number of lymphocytes decreased (43.93%), and the percentage of neutrophils decreased or normal (66.46%). Chest CT scans of 95% patients had the imaging features of pneumonia. Conclusions Clinical manifestations of the COVID-19 cases were atypical, with fever and dry cough as the main features. The patients’ hemograms were changed, and their chest CT scans showed the imaging features of pneumonia. Chest CT scan is a good auxiliary diagnostic method.
[1] 戴敏,肖阁敏,王拥泽,等.岭南新型冠状病毒肺炎临床表现的初步分析[J/OL].天津中医药.(2020-02-13).http://kns.cnki.net/kcms/detail/12.1349.R.20200213.0903.002.html. [2] 项琼,莫郑波,宋恩峰.新型冠状病毒肺炎中医理论与临床探讨[J/OL].医药导报. (2020-02-13).http://kns.cnki.net/kcms/detail/42.1293.R.20200212.2049.002.html. [3] 中华人民共和国国家卫生健康委员会.新型冠状病毒肺炎诊疗方案(试行第六版)[Z]. 2020-02-19. [4] Wang XF,Yuan J,Zheng YJ, et al.Clinical and epidemiological characteristics of 34 children with 2019 novel coronavirus infection in Shenzhen.[J/OL] Chin J Pediatr(2020-02-17).http://libdb.csu.edu.cn/rwt/SCI/. [5] 史河水,韩小雨,樊艳青,等.新型冠状病毒(2019-nCoV)感染的肺炎临床特征及影像学表现[J/OL].临床放射学杂志.(2020-02-06).https://doi.org/10.13437/j.cnki.jcr.20200206.002. [6] Chen N, Zhou M, Dong X,et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study[J/OL]. Lancet. (2020-01-30)[2020-02-15].https://www.sciencedirect.com/science/article/pii/S0140673620302117. [7] Huang C,Wang Y, Wang X,et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China[J/OL].Lancet.(2020-01-24)[2020-02-15].https://www.sciencedirect.com/science/article/pii/S0140673620301835. [8] 刘映霞, 杨扬, 张聪,等.新型冠状病毒(2019-nCoV)感染患者肺损伤相关的临床及生化指标研究[J/OL].中国科学:生命科学.(2020-02-12).http://kns.cnki.net/kcms/detail/11.5840.Q.20200212.0801.006.html. [9] 陆云飞,杨宗国,王梅,等.50例新型冠状病毒感染的肺炎患者中医临床特征分析[J/OL].上海中医药大学学报.(2020-02-10). http://kns.cnki.net/kcms/detail/31.1788.R.20200208.1112.002.html.