Abstract：Objective To explore the relationship between different levels of serum uric acid (SUA) and nonalcoholic fatty liver disease(NAFLD). Methods A total of 7,893 staff members who participated in health check-up in Kailuan General Hospital from 2011 to 2012 were selected as the research subjects. Unified questionnaire surveys, serum biochemical tests and liver ultrasound examination were performed. According to the baseline SUA measurement, the subjects were divided into 4 groups(first, second, third and forth quartile groups). The detection rates of NAFLD in various SUA groups were compared. Multiple logistic regression analysis was used to analyze the influencing factors of NAFLD. Results The detection rates of NAFLD of the 4 quartile groups were progressively increased along with the increasing level of SUA, being 29.5%, 42.5%, 50.5% and 63.9% respectively. Multiple logistic regression analysis showed that after adjusting for age, gender and other risk factors, the risk of developing NAFLD in the second, third and fourth quartile groups separately increased by 1.218 (95%CI:1.033-1.437), 1.353(95%CI:1.139-1.607)and 1.713(95%CI:1.428-2.053)times as compared with that of the first quartile group(P<0.05). Conclusions The increased SUA level is an independent risk factor for NAFLD, and it is closely related to the incidnece of NAFLD.
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