Abstract:Objective To investigate the prevalence of postpartum hypertension and its risk factors in women with a history of preeclampsia (PE). Methods A total of 860 PE women who delivered babies in Obstetrical Department of Hangzhou First People's Hospital from January 2012 to December 2016 were randomly selected as the research subjects. A prospective study was used to collect their prenatal general information, physical examination and laboratory detection data, and a follow-up was conducted to assess the prevalence of postpartum hypertension. Univariate and multivariate non-conditional logistic regression analyses were used to identify the risk factors of postpartum hypertension in the PE women. Results The prevalence rate of postpartum hypertension in the PE women was 25.36%. Single factor analysis showed that family history of hypertension, high systolic blood pressure, high diastolic blood pressure, high fasting plasma glucose (FPG), high triglyceride (TG) and high total cholesterol (TC) during the prenatal period were the risk factors of postpartum hypertension in the PE women (P<0.05). Age, history of smoking or passive smoking, drinking history, history of taking oral short-acting contraceptives, pre-pregnancy body mass index (BMI), prenatal high density lipoprotein cholesterol (HDL-C) and prenatal low density lipoprotein cholesterol (LDL-C) were not the risk factors of postpartum hypertension in the PE women (P>0.05). Multivariate analysis showed that high systolic blood pressure (OR=3.827), high diastolic blood pressure (OR=3.353), high FPG (OR=3.136) and high TG (OR=2.809) during the prenatal period were the risk factors for postpartum hypertension in the PE women. Conclusions The prevalence rate of postpartum hypertension in the PE women is relatively high, reaching 25.36%. Elevated systolicand diastolic blood pressure, high FPG and high TG during the prenatal period are all the risk factors for postpartum hypertension in the PE women.
刘蓉, 林晓峰, 魏璞, 夏建妹, 张薇. 子痫前期产妇产后高血压的发病情况及其危险因素分析[J]. 实用预防医学, 2018, 25(8): 954-957.
LIU Rong, LIN Xiao-feng, WEI Pu, XIA Jian-mei, ZHANG Wei. Prevalence and risk factors of postpartum hypertension in women with a history of preeclampsia. , 2018, 25(8): 954-957.
[1] 刘居莉, 杨焕礼. 妊娠期糖代谢监测预防妊娠相关并发症、胎儿不良结局价值分析[J]. 实用预防医学, 2017, 24(6): 723-725. [2] Joana P, Elisabete M, Tania SM, et al. Maternal plasma phospholipids are altered in trisomy 21 cases and prior to preeclampsia and preterm outcomes[J]. RCM, 2014, 28(14): 1635-1638. [3] Goetzinger KR, Zhong Y, Cahill AG, et al. Efficiency of first-trimester uterine artery doppler, a-disintegrin and metalloprotease 12, pregnancy-Associated plasma protein a, and maternal characteristics in the prediction of preeclampsia[J]. J Ultrasound Med, 2013, 32(9): 1593-1600. [4] 张健燕, 朱滨海, 朱亚萍, 等. 南京某研究所科研人员2015年高血压患病情况及危险因素分析[J]. 实用预防医学, 2016, 23(12): 1495-1498. [5] Vasudeva A, Abraham AA, Kamath A, et al. A prospective observational study of early fetal growth velocity and its association with birth weight, gestational age at delivery, preeclampsia, and perinatal mortality[J]. Eur J Radiol, 2013, 82(8): 1313-1317. [6] ACOG Committee on Obstetric Practice: ACOG practice bulletin. Diagnosis and management of preeclampsia and eclampsia[J]. Int J Gynecol Obstet, 2002, 77: 67-75. [7] 施冰, 张天阳, 刘兴余, 等. 吸烟对青年吸烟者血浆微小RNA表达谱影响的研究[J]. 中国烟草学报, 2016, 22(1): 108-113. [8] 邢丽冬, 方得胜, 钱志余, 等. 急性中度饮酒对人体脑电信号的影响[J]. 天津大学学报, 2016, 49(9): 961-966. [9] 中国高血压防治指南修订委员会.中国高血压防治指南2010[J]. 中华心血管病杂志, 2011, 39(7): 579-616. [10] Kim JS, Kang EJ, Woo OH, et al. The relationship between preeclampsia, pregnancy-induced hypertension and maternal risk of breast cancer: a meta-analysis[J]. Acta Oncol, 2013, 52(8): 1643-1648. [11] 张旋, 刘毅, 柯丽娜, 等. 影响子痫前期孕妇产后发生高血压的危险因素研究[J]. 中国性科学, 2016, 25(10): 118-123. [12] Toshitaka M, Kazushi W, Iwasaki A, et al. Differences in vascular reactivity between pregnant women with chronic hypertension and preeclampsia[J]. Hypertens Res, 2014, 37(2): 145-150. [13] Freitag N, Tirado GI, Barrientos G, et al. Interfering with Gal-1-mediated angiogenesis contributes to the pathogenesis of preeclampsia[J]. Proc Nati Acad Sci USA, 2013, 110(28): 11451-11456. [14] Koopmans CM, Vandertuuk K, Groen H, et al. Prediction of postpartum hemorrhage in women with gestational hypertension or mild preeclampsia at term[J]. Acta Obstet Gynecol Scand, 2014, 93(4): 399-407. [15] Sykes SD, Pringle KG, Zhou A, et al. Fetal sex and the circulating renin-angiotensin system during early gestation in women who later develop preeclampsia or gestational hypertension[J]. J Hum Hypertens, 2014, 28(2): 133-139. [16] Bahser N, Godehardt E, Hess AP, et al. Examination of intrarenal resistance indices indicate the involvement of renal pathology as a significant diagnostic classifier of preeclampsia[J]. Am J Hypertens, 2014, 27(5): 742-749. [17] Charlton F, Tooher J, Rye KA, et al. Cardiovascular risk, lipids and pregnancy: preeclampsia and the risk of later life cardiovascular disease[J]. Heart Lung Circ, 2014, 23(3): 203-212. [18] Wang W, Parchim NF, Iriyama T, et al. Excess LIGHT contributes to placental impairment, increased secretion of vasoactive factors, hypertension, and proteinuria in preeclampsia[J]. Hypertension, 2014, 63(3): 595-606. [19] Janzarik WG, Ehlers E, Ehmann R, et al. Dynamic cerebral autoregulation in pregnancy and the risk of preeclampsia[J]. Hypertension, 2014, 63(1): 161-166. [20] Machado ES, Krauss MR, Megazzini K, et al. Hypertension, preeclampsia and eclampsia among HIV-infected pregnant women from Latin America and Caribbean countries[J]. J Infect, 2014, 68(6): 572-580. [21] Gilbert JS, Babcock SA, Regal RR, et al. Of risks and ratios: the usefulness of angiogenic balance for diagnosing preeclampsia at different gestational ages[J]. Hypertension, 2014, 63(2): 210-211.