Abstract：Objective To study the relationship between plasma homocysteine (HCY), high sensitive C reactive protein (hs-CRP) and cognitive function in male patients with alcohol dependence. Methods One hundred and six alcohol dependence patients hospitalized in Brain Hospital of Hunan Province from June, 2015 to January, 2017 were selected as the observation group, and 100 healthy volunteers who underwent physical examination in the hospitalin the same period served as the control group. The clinical indicators and cognitive function of the two groups were detected and compared. The clinical indicators of patients with different levels ofhs-CRP and HCY in the observation group were compared, and then the correlation between cognitive function and plasma HCY, hs-CRP levels, erythrocyte parameters in patients of the observation group was analyzed. Results The endothelium dependent diastolic function (FMD) and red cell counts were both lower in the observation group than in the control group, while plasma HCY, hs-CRP levels and mean corpuscular volume (MCV) were all higher in the observation group than in the control group, showing statistically significant differences (all P<0.05). The immediate memory and visual space, language function and attention, delayed memory and the total score of Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) were all significantly lower in the observation group than in the control group, and the differences showed statistically significant (all P<0.05). Among the patients with alcohol dependence, red blood cell count and score of each dimension of cognitive function in the high HCY group were all significantly lower than those of the normal HCY group, but MCV was significantly higher than that of the normal HCY group, with statitsically significant differences (all P<0.05). Red blood cell count and score of each dimension of cognitive function in the high hs-CRP group were all significantly lower than those of the normal hs-CRP group, while MCV was significantly higher than that of the normal HCY group, showing statitsically significant differences (all P<0.05). Plasma HCY and hs-CRP levels were both negatively correlated with score of each dimension of cognitive function in patients of the observation group. There was a positive correlation between red blood cell count and delayed memory of cognitive function in patients of the observation group, but a negative correlation between MCV and language function, delayed memory, the total score of RBANS. Conclusions Plasma HCY and hs-CRP levels are closely related to cognitive function of male patients with alcohol dependence; moreover, red blood cell parameters and vascular endothelial lesions may be both involved in the process of impairment of cognitive function, which are worthy of being monitored and concerned.
杨俊,周旭辉,郭育君,罗琼. 血浆HCY、hs-CRP水平与男性酒精依赖患者认知功能的关系[J]. 实用预防医学, 2018, 25(4): 394-397.
YANG Jun, ZHOU Xu-hui, GUO Yu-jun, LUO Qiong. Relationship between plasma HCY, hs-CRP levels and cognitive function in male patients with alcohol dependence. , 2018, 25(4): 394-397.
2018, Vol. 25 
